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A comparative study on the effect of melatonin and orlistat combination versus orlistat alone on high fat diet-induced hepatic changes in the adult male albino rats (a histological and morphometric study).
Ultrastruct Pathol
January 2025
Anatomy and Embryology Department, Ain Shams University, Cairo, Egypt.
Background: Nonalcoholic fatty liver disease (NAFLD) is the extremely usual reason of chronic liver disease, extending from simple hepatic steatosis (HS), nonalcoholic steatohepatitis (NASH) to advanced hepatic fibrosis and cirrhosis. Though orlistat is a Food and Drug Administration (FDA) approved drug for long-duration management of obesity, few cases of severe hepatic insult were declared. Melatonin is an efficient antioxidant; it also regulates metabolic processes that lead to fat accumulation and obesity.
View Article and Find Full Text PDFA Simple Morphometric Analysis of Preoperative Therapy Response for Esophageal Adenocarcinoma.
Arch Pathol Lab Med
December 2024
From the Department of Pathology & Laboratory Medicine, The University of Rochester Medical Center, Rochester, New York (Ramineni, Liao, Hao).
Context.—: Histologic assessment of tumor regression grade (TRG) on esophagogastrectomy specimens after neoadjuvant therapy is an excellent predictor of local recurrence rate and long-term survival in esophageal adenocarcinomas. Although several grading systems exist globally, the modified Ryan system suggested by the College of American Pathologists (CAP) is widely used in North America.
View Article and Find Full Text PDFBrain morphometrics correlations with age among 352 participants imaged with both 3T and 7T MRI: 7T improves statistical power and reduces required sample size.
medRxiv
November 2024
Departments of Bioengineering, Psychiatry, and Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Article Synopsis
- - The study compares brain imaging results from 3 Tesla (3T) and 7 Tesla (7T) MRI to assess differences in brain morphology, focusing on signal quality and accuracy issues associated with each technology.
- - Using data from 452 healthy participants, the research employed FreeSurfer for brain segmentation, explored normalization methods for accounting variability in head size, and correlated brain measurements with age.
- - Findings indicate that 7T MRI provided stronger correlations between brain structure and age, although different normalization techniques impacted the results for 3T, with the Residual method showing better age correlation compared to the Proportional method.
Study of morphological and histological properties of the pancreas in crow () and Iraqi black partridge ().
Open Vet J
October 2024
Department of Pathology, College of Veterinary Medicine, University of Diyala, Baqubah, Iraq.
Article Synopsis
- * Both species have a pancreas with four lobes and two main types of tissue – endocrine and exocrine with notable histological variations, including the presence of centroacinar cells in black partridges but not in crows.
- * The pancreas in both birds is lobulated and located in a similar area, but the crow's pancreas is longer; further research is suggested to fully understand the functional implications of these differences.
Perches used as environmental enrichment influence fast-growth broilers' biomechanics and locomotor morphometry at the age of 42 days.
PLoS One
November 2024
Environment Livestock Research Group (NUPEA), "Luiz de Queiroz" Agriculture School (ESALQ), Department of Biosystems Engineering, University of São Paulo (USP), Piracicaba, São Paulo State, Brazil.
Currently available conventional breeding methods for broilers often result in impaired biomechanics and skeletal growth for the animals. The addition of environmental enrichment is an alternative which can help alleviate these effects. This study examines the effects of environmental enrichment on biomechanics, morphometry, and bone mass of broilers across various age groups.
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