Obtaining reliable estimates of the time-to-contact (TTC) in a three-dimensional (3D) parabolic trajectory is still an open issue. A direct analysis of the optic flow cannot make accurate predictions for gravitationally accelerated objects. Alternatively, resorting to prior knowledge of gravity and size can provide accurate estimates of TTC in parabolic head-on trajectories, but its generalization depends on the specific geometry of the trajectory and particular moments. The aim of this work is to explore the preferred viewing windows to estimate TTC and how the available visual information affects these estimations. We designed a task in which participants, wearing an head-mounted display (HMD), had to time the moment a ball in a parabolic path returned at eye level. We used five trajectories for which accurate temporal predictions were available at different points of flight time. Our results show that our observers can predict both the trajectory of the ball and TTC based on the available visual information and previous experience with the task. However, the times at which our observers chose to gather the visual evidence did not match those in which visual information provided accurate TTC. Instead, they looked at the ball at relatively fixed temporal windows depending on the trajectory but not of TTC.
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http://dx.doi.org/10.1167/jov.21.4.9 | DOI Listing |
CNS Neurosci Ther
January 2025
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Aim: Given that electroacupuncture (EA) pretreatment inhibits lactate production and lactate-derived lysine lactation (Kla) aggravates ischemic brain injury, we aimed to investigate whether the formation of Kla protein is involved in EA pretreatment to alleviate ischemic brain injury.
Methods: EA was performed on the Baihui acupoint (GV20) of male C57BL/6J mice before receiving the permanent middle cerebral artery occlusion (pMCAO) surgery. Western blot and immunofluorescent staining were used to observe neuronal survival, astrocyte activation, and protein Kla levels, and the lactate levels in ischemic brains were assayed with a commercial kit.
J Ethnopharmacol
January 2025
Department of Pharmacology, College of Medicine, Jiaxing University, Jiaxing, 314001, PR China; Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, PR China; College of Basic Medical Sciences, China Three Gorges University, Yichang 443002, PR China. Electronic address:
Ethnopharmacological Relevance: Toona sinensis fruit polyphenols (TSFP) are polyphenols that have been separated and extracted from mature Toona sinensis fruits. TSFP anti-inflammatory and neuroprotective properties have demonstrated promise. However, the underlying mechanisms require more elucidation.
View Article and Find Full Text PDFEur J Cancer
January 2025
Department of Gynecology with Breast Unit, Charité Hospital Berlin, Germany; Interdisciplinary Breast Unit, Kliniken Essen Mitte, Essen, Germany.
Background: Ribociclib + endocrine therapy (ET) showed significant progression-free survival (PFS) and overall survival (OS) benefits in the MONALEESA trials in patients with HR+ /HER2 - advanced breast cancer (ABC). We report efficacy, safety, and patient-reported outcomes (PROs) across age groups, including older patients, in these trials.
Methods: Data from the MONALEESA-2, -3, and -7 trials for pre- and postmenopausal patients receiving first-line treatment for ABC were pooled and analyzed by age (<65y, 65-74y, and ≥75y).
Brain Res
January 2025
The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 15000, China. Electronic address:
Objectives: Exercise as a non-pharmacological intervention can exert beneficial effects directly through exosomes crossing the blood-brain barrier and reduce apoptosis after cerebral ischaemia/reperfusion injury (CI/RI). miRNA-124 (miR-124) is present in exosomes and plays an important role in regulating cerebral neurological activity; however, the mechanism of the relationship between exercise and the activity of exosomes and apoptosis after CI/RI remains unclear. Therefore, the present study investigated the effects of exercise preconditioning on cerebral ischemia/reperfusion injury from the perspective of exosomal miR-124 and apoptosis.
View Article and Find Full Text PDFMicroglia M1 polarization plays important role in the development of ischemic stroke (IS). This study explored the role of transcription factor 7 like 2 (TCF7L2) in regulating microglia M1 polarization during IS. TTC staining was used to determine the cerebral infarction, and Nissl staining was applied to examine neuronal injury.
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