AI Article Synopsis
- The study looked at how different types of isoflavones (like daidzein and genistein) impact the risk of metabolic disorders in a group of 6,786 Chinese adults.
- Higher intake of total isoflavones, especially daidzein and genistein, was linked to a lower risk of conditions like non-alcoholic fatty liver disease (NAFLD), hyperlipidaemia, and hypertension.
- The research found that the relationship between isoflavone intake and metabolic disorder risks followed a nonlinear trend, indicating that more isn't always better at a consistent rate.
Article Abstract
This study investigated associations between total isoflavones and their categories (daidzein, genistein, glycitein) intake and the risks for metabolic disorders. We used the data of 6786 Chinese adults from the Nutrition Health Atlas Project. We performed multiple logistic regression and restricted cubic spline models assessing the risks for metabolic disorders (non-alcoholic fatty liver disease (NAFLD), hyperlipidaemia, hypertension, diabetes and overweight/obesity) in each category of isoflavones. Higher total isoflavones, daidzein and genistein intake were inversely associated with NAFLD ( < .05). Higher total isoflavones, daidzein, genistein and glycitein intake were also inversely associated with hyperlipidaemia ( < .01) and hypertension ( < .01). Dose-response analyses revealed that total isoflavones, daidzein, genistein and glycitein intakes were associated with the risks of metabolic disorders in a nonlinear trend. In conclusion, total isoflavones, daidzein and genistein intake were inversely associated with NAFLD, hyperlipidaemia and hypertension. Glycitein was inversely associated with hyperlipidaemia and hypertension.
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| http://dx.doi.org/10.1080/09637486.2021.1910630 | DOI Listing |
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