As we all know, the use of heroin and other drugs in Europe and more specifically in Ireland and the resulting prevalence are well documented. A huge population is still dying using heroin every day. This may happen due to, several reasons like, excessive use of painkiller, lack of awareness etc. It has also inspired mathematical modelers to develop dynamical systems predicting the use of heroin in long run. In this work, the effect of heroin in Europe has been discussed by constructing a suitable mathematical model. Our model describes the process of treatment for heroin users by consolidating a sensible utilitarian structure that speaking to the restricted accessibility of treatment. In the treatment time frame, because of the discretion of the medication clients, some kind of time delay called immunity delay might be found. The effect of immunity delay on the system's stability has been examined. The existence of positive solution and its boundedness has been established. Also, the local stability of the interior equilibrium point has been studied. Taking the immunity delay as the key parameter, the condition for Hopf-bifurcation has been studied. Using normal form theory and center manifold theorem, we have likewise talked about the direction and stability of delay induced Hopf-bifurcation. The corresponding reaction diffusion system with Dirichlet boundary condition has been considered and the Turing instability has been studied. Obtained solutions have also been plotted by choosing a suitable value of the parameters as the support of our obtained analytical results.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055444 | PMC |
http://dx.doi.org/10.1007/s40808-021-01164-x | DOI Listing |
Drugs
January 2025
Division of Endocrinology, Department of Pediatrics, College of Medicine, University of Florida, 1699 SW 16th Ave, Building A, Gainesville, FL, 32608, USA.
Type 1 diabetes mellitus (T1DM) is characterized by the progressive, autoimmune-mediated destruction of β cells. As such, restoring immunoregulation early in the disease course is sought to retain endogenous insulin production. Nevertheless, in the more than 100 years since the discovery of insulin, treatment of T1DM has focused primarily on hormone replacement and glucose monitoring.
View Article and Find Full Text PDFEur Radiol
January 2025
Department of Radiology, University of Washington, Seattle, WA, USA.
Objective: To investigate the predictive value of tumor iodine concentration obtained with dual-energy CT (DECT) for treatment response in patients treated with immune checkpoint inhibitors (ICI).
Materials And Methods: Retrospective single-center study of consecutive metastatic melanoma and renal cell carcinoma (RCC) patients undergoing first-line ICI treatment. The iodine concentration measurement time points include prior to initiation of therapy (baseline [BL]), after initiation (follow-up [FU1]), and either time point nearest to 12 months or at time of progression (final follow-up [FFU]).
J Dent Sci
January 2025
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Background/purpose: Multiple augmentation protocols are documented in the literature to rebuild the deficient alveolar ridge after tooth extraction; however, achieving adequate vertical augmentation remains the most challenging goal. This study demonstrated a novel surgical technique of early vertical ridge augmentation for post-dental extraction. This technique offers several biological and technical advantages regarding the timing of the procedure and its relative simplicity compared to other complex techniques.
View Article and Find Full Text PDFBurns Trauma
January 2025
Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang 323000, China.
Neuroregulation during skin wound healing involves complex interactions between the nervous system and intricate tissue repair processes. The skin, the largest organ, depends on a complex system of nerves to manage responses to injury. Recent research has emphasized the crucial role of neuroregulation in maximizing wound healing outcomes.
View Article and Find Full Text PDFVet Med Sci
March 2025
Department of Veterinary Medicine, National Chiayi University, Chiayi City, Taiwan.
This case report highlights a potential vaccine safety concern associated with the Pseudorabies virus (PRV) live vaccine, which warrants further investigation for comprehensive understanding. Vaccine-induced immune thrombotic thrombocytopenia (VITT), a novel syndrome of adverse events following adenovirus vector COVID-19 vaccines, was observed after vaccination with Zoetis PR-VAC PLUS. This led to a 100% morbidity and high mortality among PRV-free Danish purebred pigs from Danish Genetics Co.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!