Objective: To investigate the overall distributions of key virulence genes in , especially the hypervirulent -positive (Hv-(+)-KP).
Methods: A total of 521 complete genomes of from GenBank were collected and analyzed. Multilocus sequence typing, molecular serotyping, antibiotic-resistance, virulence genes and plasmid replicon typing were investigated.
Results: Positive rates of virulence genes highly varied, ranging from 2.9 () to 99.6% (). Totally 207 strains presented positive , , and and 190 showed positive , , , and , which were the two primary modes. A total of 94, 165 and 29 strains were denoted as hypervirulent (HvKP), (+)-KP and Hv-(+)-KP. ST11 accounted for 17 among the 29 Hv-(+)-KP strains; Genes , and were positive in 28, 26 and 18 Hv-(+)-KP strains respectively. Among the 29 Hv-(+)-KP strains exhibiting four super clusters from GenBank, IncHI1B plasmids carrying virulence genes and IncFII ones with were responsible for both 23 strains respectively.
Conclusions: Positive rates of virulence genes vary remarkably in . Genes , and were primary ones inducing Hv-(+)-KP. IncHI1B plasmids carrying virulence genes and IncFII ones with constitute the primary combination responsible for Hv-(+)-KP. The making of Hv-(+)-KP is mostly (+)-KP acquiring another plasmid harboring virulence genes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058458 | PMC |
| http://dx.doi.org/10.3389/fcimb.2021.661218 | DOI Listing |
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