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Bactericidal effect of γ-radiation with Cesium in platelet concentrates.
Transfus Apher Sci
December 2016
Centro Nacional de la Transfusión Sanguínea, Av. Othón de Mendizábal 195, Col. Zacatenco, C.P. 07360, Ciudad de México, Mexico.
Introduction: γ-radiation is a method that was originally designed for inactivation of T lymphocytes in blood and blood components in order to prevent transfusion associated-graft versus host disease (TA-GVHD). Klebsiella pneumoniae, Escherichia coli, Enterococcus faecium and Staphylococcus epidermidis strains are important pathogens in blood banks since they have been related to post-transfusional sepsis. This study was conducted to demonstrate that γ-radiation is effective in reducing the viability of bacteria in platelet concentrates (PC).
View Article and Find Full Text PDF[Epidemiological surveillance of Creutzfeldt-Jakob in France].
Rev Neurol (Paris)
November 2009
Inserm-U, Paris, France.
Introduction: Transmissible spongiform encephalopathies (TSE) have been under epidemiological surveillance in France and in Europe since the early 1990s. The observation of iatrogenic Creutzfeldt-Jakob disease (CJD), the outbreak of bovine spongiform encephalopathy (ESB) and its probable transmission to many species gave rise to the surveillance which remains warranted by the emergence of a variant of CJD (vCJD), in 1996.
State Of Art: In France, epidemiological surveillance is coordinated by the InVS which receives input from cases notifications addressed to INSERM Unit 708 directly by clinicians or more often following requests for 14-3-3 detection in CSF.
Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long term survivors after allogeneic hematopoietic stem cell transplantation (HSCT).
Haematologica
June 2007
Service d'Hématologie, Groupe Hospitalier de l'Institut CatholiqueService of Hemotherapy and Hemostasis, Hospital Clínic, Barcelona, Spain.
We quantified and studied the impact of post transfusional iron overload alone in post allogeneic HSCT. Median number of RBCs was 18. Ferritin was 532 mg/L.
View Article and Find Full Text PDFHuman platelet alloantigens (HPAs): PCR-SSP genotyping of a UK population for 15 HPA alleles.
Eur J Immunogenet
December 2003
Department of Pathology, Cambridge University, UK.
Alloimmunization to human platelet alloantigens (HPAs) is responsible for neonatal alloimmune thrombocytopenia (NAIT), post-transfusional purpura (PTP) and platelet transfusion refractoriness. HPAs may also have a role as histocompatibility antigens in transplantation as well as associations with cardiac disease. We have developed a polymerase chain reaction-sequence-specific primer (PCR-SSP) assay capable of detecting 15 HPA allelic variants.
View Article and Find Full Text PDFFactors influencing post-transfusional platelet increment in pediatric patients given hematopoietic stem cell transplantation.
Leukemia
December 2001
Department of Internal Medicine, IRCCS San Matteo-University of Pavia, Italy.
Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) always require platelet transfusions, but the increase in platelet count is often less than expected. Since factors responsible for poor response to platelet transfusions in this clinical setting are largely unknown, we performed a prospective study in 87 consecutive children transplanted in a single institution. The mean 16-h corrected count increment (CCI) of 598 platelet transfusions was 5.
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