The minimum alveolar concentration (MAC) of I-653 was determined in six beagle dogs and four New Zealand white rabbits. The MAC values (+/- SD) were 7.2 +/- 1.0 atm % for dogs and 8.9 +/- 0.3 atm % for rabbits. Comparison of these results with published MAC values for other anesthetics indicate that I-653 is one-third to one-eighth as potent as currently available volatile anesthetics (enflurane, isoflurane, and halothane). From these data and previous reports, human MAC was projected to be approximately 5.1 atm %.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00000542-198807000-00013 | DOI Listing |
Publication Analysis
Top Keywords
mac i-653
8
beagle dogs
8
dogs zealand
8
zealand white
8
white rabbits
8
mac values
8
+/- atm
8
mac
5
i-653 beagle
4
rabbits minimum
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!