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| http://dx.doi.org/10.1016/j.contraception.2021.04.009 | DOI Listing |
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Methodological challenges using routine clinical care data for real-world evidence: a rapid review utilizing a systematic literature search and focus group discussion.
BMC Med Res Methodol
January 2025
Freiburg Center for Data Analysis, Modeling and AI, University of Freiburg, Freiburg, Germany.
Background: The integration of real-world evidence (RWE) from real-world data (RWD) in clinical research is crucial for bridging the gap between clinical trial results and real-world outcomes. Analyzing routinely collected data to generate clinical evidence faces methodological concerns like confounding and bias, similar to prospectively documented observational studies. This study focuses on additional limitations frequently reported in the literature, providing an overview of the challenges and biases inherent to analyzing routine clinical care data, including health claims data (hereafter: routine data).
View Article and Find Full Text PDFFactors associated with multidrug-resistant organism (MDRO) mortality: an analysis from the national surveillance of multidrug-resistant organism, 2018-2022.
BMC Infect Dis
January 2025
Department of Public Health Medicine, Faculty of Medicine, National University of Malaysia, Federal Territory of Kuala Lumpur, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Malaysia.
Introduction: Antimicrobial resistance is a global issue, with the World Health Organization identifying it as one of the greatest threats to public health, with an estimated 4.95 million deaths linked to bacterial AMR in 2019. Our study aimed to determine the prevalence of mortality among multidrug-resistant organism (MDRO)-infected patients in state hospitals and major specialist hospitals and to identify risk factors that could be associated with mortality outcomes.
View Article and Find Full Text PDFThe modulating effect of circulating carbohydrate antigen 125 on ST2 and long-term recurrent morbidity burden.
Sci Rep
January 2025
CIBER Cardiovascular, Madrid, Spain.
Soluble ST2 (sST2) is released in response to vascular congestion, inflammation, and pro-fibrotic stimuli. In heart failure (HF), elevated levels of sST2 are associated with a higher risk of adverse clinical outcomes. Emerging evidence suggests that carbohydrate antigen 125 (CA125) may act as a ligand that modulates the inflammatory response.
View Article and Find Full Text PDFGlobal, regional and national burden of depressive disorders and attributable risk factors, from 1990 to 2021: results from the 2021 Global Burden of Disease study.
Br J Psychiatry
January 2025
Department of Scientific Research, The Second Affiliated Hospital of Anhui Medical University, Hefei, China; and Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Anhui, China.
Background: Depressive disorders pose a significant global public health challenge, yet evidence on their burden remains insufficient.
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The influence of serum uric acid on coronary atherosclerosis plaque phenotypes by computed tomography angiography: The missing link?
Nutr Metab Cardiovasc Dis
December 2024
Department of Radiology, Innsbruck Medical University, Innsbruck, Austria. Electronic address:
Background And Aims: The interaction of serum uric acid (SUA) with atherogenesis is incompletely understood. Aim of our study was to investigate the association of SUA levels with coronary plaque composition including high-risk-plaque (HRP) features by coronary computed tomography angiography (CTA) and for the prediction of major adverse cardiac events (MACE).
Methods And Results: 1242 patients (age 66.
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