Purpose: The Italian version (Granocchio et al., 2019) of the protocol proposed by Robbins and Klee (1987) allows the assessment of structure of the vocal tract, oromotor and oro-phonatory ability, and articulatory diadochokinesis in children. The aim of this study was to collect the first normative sample of Italian children.
Methods: We measured the total structural score (TSS), total functional score (TFS), oral function score (OFS), phonatory function score (PFS), maximum phonation time (MPT), speed of monosyllable repetition (SMR), and speed of polysyllable repetition (SPR) in 191 typically developing Italian children aged 2.6-6.11 years.
Results: Like the finding observed in the original protocol, there were no significant age-related changes in TSS, but the correlation was observed for TFS, OFS, PFS, MPT, SMR and SPR. The Inter-observer agreement was "good" or "excellent" for all scores except for SPR that was "moderate".
Conclusions: The increase in oro-motor, oro-phonatory and diadochokinetic abilities confirmed the progressive maturation of these functions with age. The protocol can therefore be considered a useful instrument to classify speech sound disorders (SSDs) by excluding alterations in anatomical structures and evaluate the motor impairment. This normative sample of Italian children allows to use these measures for diagnostic purposes in young Italian speakers.
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http://dx.doi.org/10.1016/j.jcomdis.2021.106101 | DOI Listing |
Human epidermal growth factor receptor 2 (HER2, also known as ERBB2) signaling promotes cell growth and differentiation, and is overexpressed in several tumor types, including breast, gastric and colorectal cancer. HER2-targeted therapies have shown clinical activity against these tumor types, resulting in regulatory approvals. However, the efficacy of HER2 therapies in tumors with HER2 mutations has not been widely investigated.
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January 2025
Centre of Applied Studies for the Sustainable Management and Protection of Mountain Areas-CRC Ge.S.Di.Mont., University of Milan, 25048, Edolo, Italy.
Saffron (Crocus sativus L.) is the most expensive spice in the World, and Italy is among the major European producers. The study aims to improve value and recognition of high quality saffron by proposing a subdivision within the first quality category, according to ISO 3632 standards.
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Forensic Medicine, Forensic Science and Sports Medicine Section, Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, Perugia, Italy. Electronic address:
Radiocarbon analysis in bones, particularly through Bomb Pulse dating, is an essential tool in forensic investigations for estimating the postmortem interval of human remains. However, there are some limitations related to the interpretation of laboratory data, since this can differ from the Post Mortem Interval by many years, depending on the anatomical district and the bone part sampled, as well as the age of the individual and other parameters, since these elements influence bone turnover. In recent years, many studies have been conducted, but with non-standardized data and on limited samples.
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. Electronic address:
Background: Hikikomori, or prolonged social withdrawal, is a clinical condition usually emerging during adolescence or young adulthood, characterized by severe self-isolation in one's home, and often associated with other psychiatric disorders and symptoms.
Objective: The study summarized evidence of hikikomori diagnostic criteria, clinical manifestations, and comorbidity with psychiatric disorders and symptoms in adolescents and young adults.
Methods: A scoping review was conducted following PRISMA guidelines, with four electronic databases searched for original works in English, French, and Italian published since 2010.
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Clinica Universidad de Navarra, Pamplona, Spain.
Direct-acting antiviral (DAA) therapy is associated with a significant reduction in hepatocellular carcinoma (HCC) incidence among patients with cirrhosis, but data are conflicting about the risk of recurrence following DAA therapy. DAA-PASS was a prospective, pragmatic, observational study designed to estimate the risk of HCC recurrence associated with DAA therapy exposure during routine clinical care. Eligible patients were DAA treatment naive with Barcelona Clinic Liver Cancer (BCLC) stage A.
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