Saldigones A-C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it's the first report of isoprenylated flavonoids from Salvia species. The structures of these isolates were elucidated by extensive spectroscopic analysis. All of the compounds were evaluated for their activities on Ca3.1 low voltage-gated Ca channel (LVGCC), of which 2 strongly and dose-dependently inhibited Ca3.1 peak current.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599534 | PMC |
| http://dx.doi.org/10.1007/s13659-021-00307-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Therapeutic Potential of Prenylated Flavonoids of the Fabaceae Family in Medicinal Chemistry: An Updated Review.
Int J Mol Sci
December 2024
Plant Proteomics and Functional Genomics Group, Department of Biochemistry and Molecular Biology and Soil and Agricultural Chemistry, Faculty of Science, University of Alicante, Carretera San Vicente del Raspeig s/n, 03690 San Vicente del Raspeig, Alicante, Spain.
Much attention has been paid to the potential biological activities of prenylated flavonoids (PFs) in various plant families over the last decade. They have enormous potential for biological activities, such as anti-cancer, anti-diabetic, antimicrobial, anti-inflammatory, anti-Alzheimer's, and neuroprotective activities. Medicinal chemists have recently shown a strong interest in PFs, as they are critical to the development of new medicines.
View Article and Find Full Text PDFEvaluation of agonistic and antagonistic effects of unprenylated and prenylated flavonoids on estrogen receptor-α.
Chem Biol Interact
December 2024
Department of Food Science and Biotechnology, Andong National University, Andong, 36729, Republic of Korea. Electronic address:
Prenylation, which involves the addition of hydrophobic molecules, is considered to enhance the bioavailability and biological activity of flavonoids. However, the effect of prenylation on the estrogenic activity of flavonoids with different structures remains unclear. This study evaluated the estrogen receptor-α (ER-α) agonistic and antagonistic activities of estrogenic flavonoids in both unprenylated and prenylated forms using OECD standardized in vitro ER-α transactivation assay and in vivo uterine hypertrophy assay.
View Article and Find Full Text PDFIsolation, characterization and biological activities of phenolics from the roots bark of Morus alba.
Phytochemistry
March 2025
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address:
Article Synopsis
- Researchers identified new compounds from the dried roots and bark of Morus alba, including two hybrids (morusalins A and B) and three previously undescribed flavonoids (morusalins C-E), along with forty-one known compounds.
- The structures of these compounds were determined using advanced techniques such as NMR spectroscopy, mass spectrometry, and X-ray diffraction.
- The study also tested the compounds for their effects on nitric oxide production in murine macrophage cells and their cytotoxicity against human colon and liver cancer cells, proposing a biosynthetic pathway for the new compounds.
Xanthohumol ameliorates dextran sodium sulfate-induced colitis in mice by inhibiting of NF-κB signaling pathways and modulating intestinal microbiota.
Eur J Nutr
November 2024
Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Ethnopharmacological Relevance: Xanthohumol (XN), an isoprenylated flavonoid natural product found only in hops, possesses a variety of biological activities such as anticancer, anti-inflammatory, hepatoprotective, and anti-obesity.
Aim Of The Study: The aim of this study was to investigate the effects and mechanisms of XN on the treatment of colitis.
Materials And Methods: First, acute colitis was induced by using distilled water containing 3% DSS for 10 consecutive days.
A rare prenylated isoflavone-quinone from the roots of .
J Asian Nat Prod Res
January 2025
School of Pharmacy, Shenyang Medical College, Shenyang110034, China.
In order to make more rational use of , a systematic separation from the roots of was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (), together with four known analogues (). Their structures were established by extensive physical and spectroscopic data analysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!