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Article Synopsis
  • Antitumoral drugs (ADs) can trigger hypersensitivity reactions (DHRs), and rapid drug desensitization (RDD) protocols are employed to safely administer these treatments at effective doses.
  • The "DESARCh" retrospective study assessed the RDD protocols carried out at an Italian hospital over 11 years, including a detailed 5-step infusion method to reduce DHR incidence for patients with various cancers.
  • Out of 66 RDD protocols for 25 female patients, the overall success rate was 81.82%, although carboplatin had a significantly lower success rate compared to other ADs, highlighting the need for further research in this area.
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Introduction: Taxanes and platinum are first-line treatments in gynecological tumors with high rates of hypersensitivity reactions (HSRs), leading to discontinuation of treatment. Desensitization involves induction of temporary tolerance to previously sensitized medications. The aims of this study are to describe HSRs to paclitaxel and carboplatin and evaluate the safety and effectiveness of desensitization protocols in gynecological cancer patients.

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Purpose: Unresectable pediatric low-grade gliomas (LGG) usually need adjuvant therapy, and carboplatin hypersensitivity reaction (HR) commonly leads to premature treatment cessation of a standard chemotherapy regimen. In the molecular era, advances in understanding tumor genetic characteristics allowed the development of targeted therapies for this group of tumors; however, cost-effectiveness assessment of treatments, especially in low-income countries, is crucial. The aim is to describe the results of carboplatin desensitization protocol in a single center in a middle-income country.

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Article Synopsis
  • Hypersensitivity reactions (HSRs) to chemotherapy, particularly carboplatin, are significant adverse events that can affect cancer drug therapy, prompting a study on desensitization methods.
  • The study included 136 patients with gynecological cancers undergoing carboplatin desensitization therapy between 2016 and 2020, tracking their treatment responses and HSR symptoms.
  • Findings revealed a 75% success rate for desensitization, with common symptoms like erythema and itching, while no deaths occurred during the study, indicating the need for awareness of potential HSRs.
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Carboplatin desensitization - simplified 4-step 2-bag method.

J Oncol Pharm Pract

June 2024

Department of Allergy/Immunology, Corewell Health Medical Group West, Grand Rapids, MI, USA.

Introduction: Our cancer program adopted a method for carboplatin desensitization (4-step 2-bag method) that administers the same intensity of drug exposure with a simplified approach to product management in comparison to a published protocol (4-step 4-bag method).

Methods: The intensity of carboplatin administration for 1:1,000, 1:100, 1:10, and 1:1 dilutions and concomitant fluid administration were compared for the 4-step 2-bag (bags A, B) and 4-step 4-bag (bags 1, 2, 3, 4) methods. Pharmacy preparation of bags A and B is described.

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