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http://dx.doi.org/10.1111/pai.13525 | DOI Listing |
Hosp Pharm
September 2024
Medical Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.
J Oncol Pharm Pract
August 2024
Oncology Service, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr José Eleuterio González", Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
Introduction: Taxanes and platinum are first-line treatments in gynecological tumors with high rates of hypersensitivity reactions (HSRs), leading to discontinuation of treatment. Desensitization involves induction of temporary tolerance to previously sensitized medications. The aims of this study are to describe HSRs to paclitaxel and carboplatin and evaluate the safety and effectiveness of desensitization protocols in gynecological cancer patients.
View Article and Find Full Text PDFChilds Nerv Syst
December 2024
Department of Pediatrics' Allergy, Immunology, and Rheumatology- Federal University of Sao Paulo, Sao Paulo, Brazil.
Purpose: Unresectable pediatric low-grade gliomas (LGG) usually need adjuvant therapy, and carboplatin hypersensitivity reaction (HR) commonly leads to premature treatment cessation of a standard chemotherapy regimen. In the molecular era, advances in understanding tumor genetic characteristics allowed the development of targeted therapies for this group of tumors; however, cost-effectiveness assessment of treatments, especially in low-income countries, is crucial. The aim is to describe the results of carboplatin desensitization protocol in a single center in a middle-income country.
View Article and Find Full Text PDFCancer Med
March 2024
Department of Obstetrics and Gynecology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
J Oncol Pharm Pract
June 2024
Department of Allergy/Immunology, Corewell Health Medical Group West, Grand Rapids, MI, USA.
Introduction: Our cancer program adopted a method for carboplatin desensitization (4-step 2-bag method) that administers the same intensity of drug exposure with a simplified approach to product management in comparison to a published protocol (4-step 4-bag method).
Methods: The intensity of carboplatin administration for 1:1,000, 1:100, 1:10, and 1:1 dilutions and concomitant fluid administration were compared for the 4-step 2-bag (bags A, B) and 4-step 4-bag (bags 1, 2, 3, 4) methods. Pharmacy preparation of bags A and B is described.
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