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Management of overlapping immune-related myocarditis, myositis, and myasthenia in a young patient with advanced NSCLC: a case report.
Front Oncol
October 2024
Department of Clinical and Molecular Medicine, Oncology Unit, Sant' Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
Immunotherapy is increasingly used in advanced non-small-cell lung cancer (NSCLC), offering a significant anti-tumor response, as well as causing rising immune-related adverse effects. The incidence of immune checkpoint inhibitor-induced myocarditis-myositis-myasthenia gravis is increasing and particularly concerning due to its high mortality rate. Prompt recognition, diagnosis, and management are crucial.
View Article and Find Full Text PDFCoexisting anti-MDA5 and anti-PL-7 antibodies are extremely rare. Anti-MDA5 is associated with rapidly progressive interstitial lung disease (RP-ILD), while anti-PL-7 is often associated with chronic or subacute ILD and better outcomes than RP-ILD. We report a 41-year-old woman diagnosed with dermatomyositis (DM)-associated ILD positive for anti-MDA5 and anti-PL-7.
View Article and Find Full Text PDFCOVID-19 Related Myocarditis and Myositis in a Patient with Undiagnosed Antisynthetase Syndrome.
Biomedicines
December 2022
Department of Cardiology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Background: The clinical presentation of SARS-CoV-2 varies from patient to patient. The most common findings noted were respiratory tract infections, of different severity grades. In some cases, multi-organ damage was noted.
View Article and Find Full Text PDFNew-onset dermatomyositis following COVID-19: A case report.
Front Immunol
November 2022
Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Most of the infected individuals have recovered without complications, but a few patients develop multiple organ involvements. Previous reports suggest an association between COVID-19 and various inflammatory myopathies, in addition to autoimmune diseases.
View Article and Find Full Text PDFClinical and autoantibody phenotypes of juvenile dermatomyositis.
Reumatologia
September 2022
Ternopil Regional Children's Hospital, Ternopil, Ukraine.
Juvenile dermatomyositis (JDM) is a heterogeneous autoimmune inflammatory myositis with symmetrical proximal muscle weakness and a characteristic rash. Juvenile dermatomyositis is characterized by variable presentation and phenotypes. Detection of myositis autoantibodies is useful in improving JDM diagnosis and predicting the prognosis.
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