AI Article Synopsis
- The aqueous extract of Ocimum selloi (alfavaca) is traditionally used for pain and inflammation, prompting research into its properties.
- The study analyzed the chemical composition and anti-inflammatory effects of the leaves' aqueous extract (OSAE) and essential oil (OSEO) using various tests on mice models.
- Results show that both OSAE and OSEO have significant anti-inflammatory and pain-relieving effects, with specific dosages effectively reducing inflammation and sensitivity, validating their popular medicinal use.
Article Abstract
Ethnopharmacological Relevance: The population uses the aqueous extract as tea from leaves of Ocimum selloi Benth. (alfavaca) for pain and inflammation issues. This study is motivated by a lack of data about inflammation properties of O. selloi.
Aim Of The Study: This study investigated the chemical composition and anti-inflammatory activity, in mice models, of the aqueous extract (OSAE) and essential oil (OSEO) obtained from leaves of O. selloi.
Materials And Methods: The antioxidant activity and total phenolic content were evaluated for samples, although chemical composition was obtained by U-HPLC-DAD-ESI-MS for OSAE and GC-MS for OSEO. OSAE and OSEO were tested orally at doses of 30, 100 and 300 mg/kg at the carrageenan-induced pleurisy and paw edema, also mechanical hyperalgesia, in mice.
Results: Four glycosylated flavonoids and one organic acid were identified in OSAE, and nine substances in OSEO, the two majoritarian are E-anethole and methyl chavicol. Oral treatments with OSAE and OSEO significantly inhibited the carrageenan-induced pleurisy in female Swiss mice, besides OSAE and OSEO significantly prevented paw edema (after 1, 2, and 4 h), mechanical hyperalgesia (after 3 and 4 h), and cold hyperalgesia 3 h after carrageenan model in male Swiss mice. The dose of 300 mg/kg of OSEO reduced cold hyperalgesia 4 h after carrageenan.
Conclusion: The results evidenced the anti-inflammatory, anti-edematogenic, anti-hyperalgesic, and anti-nociceptive potentials of both materials obtained from leaves of O. selloi, mainly OSAE, supporting the popular use of this species.
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| http://dx.doi.org/10.1016/j.jep.2021.114136 | DOI Listing |
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