Ti-xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti-xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti-xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi). Ti-45Zr had the optimum strength/elastic modulus ratio and osteogenic activity, thus is a promising to used as dental implants.
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| http://dx.doi.org/10.1007/s10856-021-06522-w | DOI Listing |
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Cytocompatibility of Ti-xZr alloys as dental implant materials.
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State Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, PR China.
Ti-xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti-xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti-xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi).
View Article and Find Full Text PDFMicrostructure, mechanical properties, and preliminary biocompatibility evaluation of binary Ti-Zr alloys for dental application.
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1 State Key Laboratory of Powder Metallurgy, Central South University, Changsha, China.
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