Genetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field.

Nanomedicine (Lond)

Department of Radiology, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea.

Published: April 2021

AI Article Synopsis

  • The study investigates how manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field affect glioblastoma cells (U-87MG).
  • Results showed that MFMNPs increased the uptake in these cells and, combined with a magnetic field, elevated specific mRNA levels tied to the Wnt/β-catenin signaling pathway.
  • This combination also led to faster tumor growth and lower survival rates in animal tests, indicating a potential negative impact on glioblastoma progression.

Article Abstract

To confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field on glioblastoma cells. U-87MG glioblastoma cells were prepared, into which the uptake of MFMNPs was high. The cells were then exposed to an external magnetic field using a neodymium magnet and . and mRNA levels involved in the Wnt/β-catenin signaling pathway were elevated by the influence of MFMNPs and the external magnetic field. MFMNPs and the external magnetic field also accelerated tumor growth by approximately 7 days and decreased survival rates in animal experiments. When MFMNPs and an external magnetic field are applied for a long time on glioblastoma cells, mRNA expression related to Wnt/β-catenin signaling is increased and tumor growth is promoted.

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Source
http://dx.doi.org/10.2217/nnm-2020-0399DOI Listing

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