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Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation.
Pharmaceutics
June 2024
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
Binder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2-40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was identified as an effective binder during TSWG, but the potential of other PVA grades-differing in polymerization and hydrolysis degree-has not yet been studied. Therefore, the aim of the current study was to evaluate the potential of different PVA grades as a binder during TSWG.
View Article and Find Full Text PDFBatch-wise occurring dermatitis with acral emphasis and infestation of the oral mucosa.
J Dtsch Dermatol Ges
September 2021
Department of Dermatology and Allergology, SRH Wald-Klinikum Gera GmbH, Gera, Germany.
Controlled supramolecular polymerization of π-systems.
Chem Commun (Camb)
June 2020
School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation Science, 2A and 2B Raja S. C. Mullick Road, Kolkata, 700032, India.
Supramolecular polymers, albeit having precise internal order, largely lack precision in the mesoscopic scale because in most examples supramolecular polymerization occurs under thermodynamic control through spontaneous self-assembly. Recent reports have exemplified that by varying experimental parameters including cooling rate, solvent composition, interplay of intra- vs. inter-molecular H-bonding and others, it is possible to retard the spontaneous nucleation, and isolate a dormant kinetically controlled monomeric/aggregated state which in turn can serve as the monomer pool to undergo controlled supramolecular polymerization (CSP) through a chain-growth mechanism in the presence of an aggregated/molecular initiator (seed) or by an external stimuli like light.
View Article and Find Full Text PDFThe mechanisms of granulation of activated sludge in wastewater treatment, its optimization, and impact on effluent quality.
Appl Microbiol Biotechnol
June 2018
Department of Chemistry and Molecular Biology, University of Gothenburg, SE-405 30, Gothenburg, Sweden.
Granular activated sludge has gained increasing interest due to its potential in treating wastewater in a compact and efficient way. It is well-established that activated sludge can form granules under certain environmental conditions such as batch-wise operation with feast-famine feeding, high hydrodynamic shear forces, and short settling time which select for dense microbial aggregates. Aerobic granules with stable structure and functionality have been obtained with a range of different wastewaters seeded with different sources of sludge at different operational conditions, but the microbial communities developed differed substantially.
View Article and Find Full Text PDFElectrochemical inactivation of cyanobacteria and microcystin degradation using a boron-doped diamond anode - A potential tool for cyanobacterial bloom control.
J Environ Sci (China)
March 2017
Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna pot 111, SI-1000 Ljubljana, Slovenia. Electronic address:
Cyanobacterial blooms are global phenomena that can occur in calm and nutrient-rich (eutrophic) fresh and marine waters. Human exposure to cyanobacteria and their biologically active products is possible during water sports and various water activities, or by ingestion of contaminated water. Although the vast majority of harmful cyanobacterial products are confined to the interior of the cells, these are eventually released into the surrounding water following natural or artificially induced cell death.
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