Hypersensitivity reactions to dapsone are common and potentially fatal adverse drug reactions. Herein, we report a case of a 45-year-old female who presented with fever, generalized desquamating rashes, and icterus three weeks after initiation of dapsone therapy for leprosy neuritis. She was diagnosed to have dapsone hypersensitivity syndrome (DHS) with leukemoid reaction and thrombocytosis. Dapsone was immediately discontinued, and she has treated with prednisolone 50 mg daily for a month and tapered over the next month. She has improved completely. DHS, leukemoid reaction, and severe thrombocytosis, or these adverse drug reactions to dapsone have rarely been reported.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057120 | PMC |
| http://dx.doi.org/10.7759/cureus.14026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Factors distinguishing leukemoid reaction from hematological malignancy in children.
Pediatr Int
December 2024
Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
Article Synopsis
- The study focused on understanding leukemoid reaction (LR) in children and how it differs from hematological malignancy (HM), revealing limited knowledge on their etiology and prognosis.
- Researchers analyzed 214 pediatric cases with high white blood cell counts, finding that about 50% of LR cases were linked to infections like bacteremia and respiratory illnesses.
- Key predictive factors for LR included age under 2, presence of underlying conditions, and specific lab results; despite higher mortality in the LR group (13% vs. 6%), the difference wasn't statistically significant.
Post-transplant transient abnormal myelopoiesis evolving from a GATA1 mutant clone in umbilical cord blood.
Ann Hematol
December 2024
Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Transient abnormal myelopoiesis (TAM) generally affects newborns with Down syndrome and is associated with constitutional trisomy 21 and a somatic GATA1 mutation. Here we describe a case of TAM which evolved after umbilical cord blood transplantation (UCBT), whose origin was identified as a GATA1 mutation-harboring clone in umbilical cord blood (UCB) by detailed genetic analyses. A 58-year-old male who received UCBT for peripheral T-cell lymphoma presented progressive anemia and thrombocytopenia, and leukocytosis with blast cells in the peripheral blood (PB).
View Article and Find Full Text PDFAcute Pancreatitis and Leukemoid Reaction as the Presenting Manifestation of Hemorrhagic Fever with Renal Syndrome: A Case Report.
Infect Drug Resist
November 2024
Department of Emergency, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.
Article Synopsis
- Hemorrhagic fever with renal syndrome (HFRS), caused by Orthohantavirus hantanense, presents with symptoms like fever and kidney issues, but can also involve rare conditions like acute pancreatitis and leukemoid reaction.
- A case study of a 20-year-old male showed severe symptoms that led to hospitalization and a positive HTNV antibody test, highlighting the challenges in diagnosing HFRS when symptoms are atypical.
- The study stresses the need for healthcare professionals to identify unusual HFRS symptoms early and use a comprehensive treatment approach to enhance patient outcomes, especially in areas where the disease is common.
Autopsy case of a stillbirth with transient abnormal myelopoiesis associated with Down syndrome: Immunohistochemical demonstration of GATA1 mutation in placental tissues.
Pathol Int
December 2024
Department of Obstetrics and Gynecology, Saiseikai Kawaguchi General Hospital, Kawaguchi, Japan.
Article Synopsis
- Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) presents similarly to acute megakaryoblastic leukemia but usually resolves on its own within months postpartum.
- Some cases of TAM can lead to severe health issues, impacting the patient's prognosis negatively.
- An autopsy of a stillborn female with TAM and DS revealed GATA1s protein expression in unusual immature megakaryocytes, indicating that placental tissue can be useful for diagnosing TAM histologically.
Tigecycline-Induced Leukemoid Reaction in a Burn Patient: A Case Report.
Cureus
September 2024
Plastic Surgery, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Article Synopsis
- Tetracycline antibiotics can cause rare side effects like drug fever and leukemoid reaction (LR).
- A case is presented involving a burn patient who experienced LR due to tigecycline.
- This case is noted as the first global report of tigecycline-induced drug fever and LR specifically in a burn patient, and the second overall.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!