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| http://dx.doi.org/10.3389/fendo.2021.660381 | DOI Listing |
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Improvement in biochemical manifestations of the serum and follicular fluid and ICSI outcomes in PCOS patients with myo-inositol administration: prospective randomized research.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Biology, Parand Branch, Islamic Azad University, Bahonar Blvd, Tehran, Iran.
The research investigated the capacity of myo-inositol (MI) in order that it improves biochemical markers in serum and follicular fluid and, ultimately, intracytoplasmic sperm injection (ICSI) outcomes of women with PCOS. Sixty infertile patients with PCOS, who were undergoing ovulation induction for ICSI, were randomly divided to two groups. The MI group received 2000 mg myo-inositol + 1 mg folic acid twice a day for 6 weeks with starting the ICSI cycle.
View Article and Find Full Text PDFComparative efficacy and safety of metformin, anti-obesity agents, and myoinositol in improving IVF/ICSI outcomes and reducing ovarian hyperstimulation syndrome in women with polycystic ovary syndrome: a systematic review and network meta-analysis.
J Ovarian Res
December 2024
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Purpose: To compare the efficacy and safety of metformin, anti-obesity agents, and inositol with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
Methods: A comprehensive search was conducted in PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov for studies published in English up to October 26, 2024.
Article Synopsis
- Myo-inositol (MYO) and D-chiro-inositol (DCI) are key inositol isomers crucial for cell signaling, with MYO being the most prevalent in nature and DCI derived from MYO through insulin-dependent processes.
- In women with conditions like PCOS, the MYO/DCI ratio shifts significantly, impacting oocyte quality and contributing to increased androgen levels, while MYO supplementation can enhance embryo quality in fertility treatments.
- Inositol may also help mitigate gestational diabetes risks during pregnancy, suggesting that dietary supplementation could be a beneficial approach for improving female fertility and supporting healthy pregnancies.
Diacerein and myo-inositol alleviate letrozole-induced PCOS via modulation of HMGB1, SIRT1, and NF-kB: A comparative study.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Medical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, 32511, Egypt.
Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility in women. Myo-inositol supplementation has displayed effectiveness in curing PCOS patients. Diacerein, an anti-inflammatory medication, has not been extensively studied in the context of reproductive disorders.
View Article and Find Full Text PDFCausal relationship between fertility nutrients supplementation and PCOS risk: a Mendelian randomization study.
Front Endocrinol (Lausanne)
October 2024
Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a common condition among reproductive-age women, with few effective treatment options; research suggests fertility nutrient supplements might help, but their influence on PCOS risk is unclear.
- This study used Mendelian Randomization to analyze 10 specific fertility nutrients, including omega-3 fatty acids and curcumin, to determine their causal effect on PCOS risk.
- Results showed that omega-3 fatty acids can reduce PCOS risk while betaine increases it; certain nutrients like berberine and curcumin also demonstrated potential protective roles against PCOS.
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