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| http://dx.doi.org/10.1590/0037-8682-0044-2021 | DOI Listing |
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Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial.
Front Child Adolesc Psychiatry
January 2023
Department of Child and Adolescent Psychological Medicine, University of Fukui Hospital, Fukui, Japan.
Reactive attachment disorder (RAD) is associated with socially and emotionally withdrawn/inhibited behaviors and reduced neural responses to rewards. Children and adolescents with RAD show aberrant attachment behaviors, and existing psychotherapies are difficult to maintain; therefore, pharmacological interventions to aid and boost treatment responses are needed. Oxytocin (OT) administration is known to promote reward functioning.
View Article and Find Full Text PDFEpilepsy, compulsion and oxytocin: Insights from behavioral sequences, using neuroethology and complexity systems approaches.
Epilepsy Behav
January 2025
Physiology Department, Ribeirão Preto, School of Medicine, University of São Paulo, (USP), Ribeirão Preto, Brazil; Neuroscience and Behavioral Sciences Department, Ribeirão Preto, School of Medicine, University of São Paulo, (USP), Ribeirão Preto, Brazil. Electronic address:
Epilepsies are complex neurological entities usually co-existing with neuropsychiatric comorbidities. We already demonstrated that microinjection of oxytocin (OT) into the central nucleus of amygdala (CeA) induces hypergrooming in Wistar rats, a model of compulsion. Furthermore, the Wistar Audiogenic Rat (WAR) strain is a genetic model of generalized tonic-clonic seizures.
View Article and Find Full Text PDFDisentangling the neural underpinnings of response inhibition in disruptive behavior and co-occurring ADHD.
Eur Child Adolesc Psychiatry
January 2025
Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
While impaired response inhibition has been reported in attention-deficit/hyperactivity disorder (ADHD), findings in disruptive behavior disorders (DBDs) have been inconsistent, probably due to unaccounted effects of co-occurring ADHD in DBD. This study investigated the associations of behavioral and neural correlates of response inhibition with DBD and ADHD symptom severity, covarying for each other in a dimensional approach. Functional magnetic resonance imaging data were available for 35 children and adolescents with DBDs (8-18 years old, 19 males), and 31 age-matched unaffected controls (18 males) while performing a performance-adjusted stop-signal task.
View Article and Find Full Text PDFUnlabelled: Early skill learning develops in the context of activity changes in distributed cortico-subcortical regions. Here, we investigated network hubs-centers of information integration and transmission-within the brain network supporting early skill learning. We recorded magnetoencephalographic (MEG) brain activity in healthy human subjects who learned a moderately difficult sequence skill with their non-dominant left hand.
View Article and Find Full Text PDFUbiquitin specific peptidase 11 knockdown slows Huntington's disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway.
Mol Med
January 2025
Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Background: Mitochondrial dysfunction and neuronal damage are major sign of cytopathology in Huntington's disease (HD), a neurodegenerative disease. Ubiquitin specific peptidase 11 (USP11) is a deubiquitinating enzyme involved in various physiological processes through regulating protein degradation. However, its specific role in HD is unclear.
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