A protecting group-free approach for synthesizing C-glycosides through glycosyl dithiocarbamates.

Org Biomol Chem

Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 6-6-07, Aoba, Aoba-ku, Sendai, 980-8579 Japan.

Published: April 2021

The first protection/deprotection-free process for radical C-glycosylation has been achieved through one-step preparable glycosyl dithiocarbamates (GDTCs). The Giese-type reaction and radical allylation of unprotected GDTCs were successfully performed to obtain the corresponding α-C-glycosides stereoselectively under mild reaction conditions.

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Source
http://dx.doi.org/10.1039/d1ob00311aDOI Listing

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