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Myrindole A, an Antimicrobial Bis-indole from a Marine Sponge sp. | LitMetric
Myrindole A, a bis-indole alkaloid, was isolated from the deep-sea sponge sp. The high degree of unsaturation of the molecule complicated the assignment of its structure by standard 2D-NMR experiments but was ultimately achieved by a combination of H-N-HMBC and 1,-ADEQUATE experiments as well as the comparison of measured and calculated CD spectra. Myrindole A showed antimicrobial activity against Gram-positive and Gram-negative bacteria.
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