AI Article Synopsis
- The increase in antibiotic resistance poses a significant global health threat, with new research revealing that non-antibiotic chemicals, like herbicides, may contribute to this issue.
- Exposure to three common herbicides (glyphosate, glufosinate, and dicamba) was found to alter the antibiotic sensitivity of the model strain DH5, particularly enhancing its resistance to gentamicin and other antibiotics over time.
- Whole-genome sequencing indicated that these herbicides can cause genetic mutations in bacteria, which may further encourage the spread of antibiotic resistance genes in various environments.
Article Abstract
The spread of antibiotic resistance has become a serious threat to global public health. Recently, several studies have found that non-antibiotic chemicals can promote the generation and spread of bacterial antibiotic resistance. However, the effects of herbicides on the antibiotic resistance of bacteria remain unclear. In this study, DH5 was used as the model strain to explore the effects of three commonly used herbicides (glyphosate, glufosinate, and dicamba) on the antibiotic resistance under soil environmental concentrations. The results showed that herbicide exposure affected the sensitivity of DH5 to antibiotics and significantly improved the resistance of DH5 to gentamicin (glyphosate > dicamba > glufosinate). After 30 d of herbicide exposure, the mutant strains enhanced the resistance to tetracycline, chloramphenicol, and aminoglycoside antibiotics, and the minimum inhibitory concentration of streptomycin was increased by 19.8 times. The whole-genome sequencing results illustrated that herbicides induced several previously well-characterized mutations associated with membrane proteins ( and ), fimbriae proteins (), and ribosomes () related to antibiotic resistance. Together, the results showed that herbicides can enhance the antibiotic resistance of bacteria via inducing genetic mutations, thereby promoting the potential risk of the spread of antibiotic resistance genes in the environment.
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| http://dx.doi.org/10.13227/j.hjkx.202009249 | DOI Listing |
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