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Comparative taste-masking evaluation of microencapsulated bitter drugs using Smartseal 30D and ReadyMix for paediatric dosage forms. | LitMetric

AI Article Synopsis

  • * The drugs were microencapsulated using a spray-drying process at specific loadings, with the approach optimized for yield and encapsulation efficiency, followed by a physicochemical characterization to assess the drugs' physical state in the microparticles.
  • * An evaluation using a human taste panel confirmed that the encapsulated drugs had significantly reduced bitterness compared to their unencapsulated forms at all tested loadings.

Article Abstract

The taste of drug substances plays a key role in the development of paediatric formulations with suitable organoleptic properties. The aim of the study was to evaluate the taste masking effectiveness of Smartseal 30D and ReadyMix on a range of bitter drug substances such as diphenhydramine HCl (DPD), ibuprofen lysine (IBU-LS), and phenylephrine HCl (PPH) for the development of paediatric dosage forms. The drugs were microencapsulated in the polymer carriers at 10-20% loadings using spray-drying processing. Spray drying of drug formulations was optimized in terms of percent yield and encapsulation efficiency followed by physicochemical characterization in order to identify the drugs' physical state in the polymer microparticles. The in vivo taste masking efficiency was evaluated using human test panel and showed noticeable reduction of drug's bitterness at all loadings in comparison to the bulk substances.

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Source
http://dx.doi.org/10.1208/s12249-021-02002-0DOI Listing

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