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| http://dx.doi.org/10.1542/peds.2021-050212 | DOI Listing |
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Impact of Extracorporeal Membrane Oxygenation Circuitry on Remdesivir.
J Pediatr Pharmacol Ther
June 2024
The Center for Pediatric Pharmacotherapy LLC (JJC, WSM, AC), Pottstown, PA.
Objectives: This study aimed to determine the oxygenator impact on alterations of remdesivir (RDV) in a contemporary neonatal/pediatric (1/4-inch) and adolescent/adult (3/8-inch) extracorporeal membrane -oxygenation (ECMO) circuit including the Quadrox-i oxygenator.
Methods: One-quarter-inch and a 3/8-inch, simulated closed-loop ECMO circuits were prepared with a Quadrox-i pediatric and Quadrox-i adult oxygenator and blood primed. Additionally, 1/4-inch and 3/8-inch circuits were also prepared without an oxygenator in series.
Insulin and Metformin Administration: Unravelling the Multifaceted Association with Mortality across Various Clinical Settings Considering Type 2 Diabetes Mellitus and COVID-19.
Biomedicines
March 2024
Clinical Department of Diabetology and Internal Disease, Wroclaw Medical University, Borowska Street 213, 50-556 Wroclaw, Poland.
Due to the molecular mechanisms of action of antidiabetic drugs, they are considered to be effective in the treatment of both COVID-19 and the post-COVID-19 syndromes. The aim of this study was to determine the effect of administering insulin and metformin on the mortality of patients with type 2 diabetes (T2DM) with symptomatic COVID-19 with the use of logistic regression models. The association between death and insulin and metformin was weak and could not be included in the multivariate model.
View Article and Find Full Text PDFPreliminary report on therapeutic potential of coal-derived carbon quantum dots against SARS-CoV-2 virus.
Virology
May 2024
Centre for Pre-clinical Studies (CPS), CSIR-North East Institute of Science and Technology, Jorhat, 785006, Assam, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India.
Due to the pandemic of COVID-19 and subsequent emerging of new mutant strains, there has been a worldwide hunt for therapeutic and protective agents for its inhibition. In this short communication, for the first time, we report the coal-derived carbon quantum dot (CQD) for the possible therapeutic application against SARS-CoV-2. The synthesized C1-CQD is observed to be safe towards the normal cell line at highest dose, while effectively inhibiting growth of SARS-CoV2 (>95%) with IC value of 5.
View Article and Find Full Text PDFIdentification of oral therapeutics using an AI platform against the virus responsible for COVID-19, SARS-CoV-2.
Front Pharmacol
December 2023
Department of Urologic Sciences, Faculty of Medicine and the Neglected Global Diseases Initiative, University of British Columbia, Vancouver, BC, Canada.
This study introduces a sophisticated computational pipeline, , designed for the discovery of antiviral drugs based on their interactions within the human protein network. There is a pressing need for cost-effective therapeutics for infectious diseases (e.g.
View Article and Find Full Text PDFIs antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review.
Infection
February 2024
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Article Synopsis
- The review explores whether antiviral medications given during the acute phase of COVID-19 can help reduce the risk of developing long-COVID symptoms.
- A comprehensive search of various medical databases identified 7 relevant studies, with high methodological quality in most.
- The findings are mixed, with some antivirals like Remdesivir showing potential benefits, while other drugs like Dexamethasone and Metformin also showed promise, though more research is necessary to make definitive conclusions.
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