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Sudden sensorineural hearing loss (SSNHL) presents as the abrupt onset of hearing loss. Approximately 88% of SSNHL has no identifiable etiology and is termed idiopathic sudden sensorineural hearing loss (ISSHL). Hearing specialists have investigated ISSHL since the 1970s.
View Article and Find Full Text PDFMathematical modeling of impacts of patient differences on renin-angiotensin system and applications to COVID-19 lung fibrosis outcomes.
Comput Biol Med
January 2025
Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA; Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA; Institute for Artificial Intelligence and Data Science, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA; Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, The State University of New York, Buffalo, NY, 14203, USA; Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, 14215, USA. Electronic address:
Article Synopsis
- Patient-specific factors like age, sex, and existing health conditions significantly impact the severity of lung diseases, including COVID-19-related fibrosis, with the renin-angiotensin system (RAS) playing a key regulatory role.
- Recent studies show conflicting results regarding changes in RAS peptides post-SARS-CoV-2 infection, necessitating a multiscale computational model that integrates various factors to assess the systemic effects of RAS during COVID-19.
- The model indicates that inflammation leads to reduced ACE and ACE2 levels, with variations in RAS peptide changes across different patient demographics, suggesting potential for personalized treatment approaches in lung disease management.
POST-RADIATION NEUROCOGNITIVE DEFICIT IN THE CHORNOBYL CLEAN-UP WORKERS: GERIATRIC ASPECTS (PART І).
Probl Radiac Med Radiobiol
December 2024
State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
Objective: to study the features of cognitive disorders in the remote period following exposure to ionizing radiation (IR) in the elderly participants of the liquidation of the consequences of the Chornobyl NPP accident (Chornobyl clean-up workers) with chronic cerebrovascular disorders.
Materials And Methods: The retrospective and prospective cohort study with the external and internal controlgroups. The randomized sample of the male elderly participants (attained age more than 60 years old) in liquidationof the consequences of the accident (Chornobyl clean-up workers, liquidators) at the Chornobyl nuclear power plant(ChNPP) in 1986-1987 (main group, n = 52) recruited from the Clinico-epidemiological registry (CER) of StateInstitution «National Research Center for Radiation Medicine, Hematology and Oncology of The National Academyof Medical Sciences of Ukraine» (NRCRMHO) with verified chronic cerebrovascular disorders (CVD) was examined.
Variations of blood D-serine and D-aspartate homeostasis track psychosis stages.
Schizophrenia (Heidelb)
December 2024
CEINGE Biotecnologie Avanzate Franco Salvatore, Naples, Italy.
Schizophrenia (SCZ) is a severe psychotic disorder characterized by a disruption in glutamatergic NMDA receptor (NMDAR)-mediated neurotransmission. Compelling evidence has revealed that NMDAR activation is not limited to L-glutamate, L-aspartate, and glycine since other free amino acids (AAs) in the atypical D-configuration, such as D-aspartate and D-serine, also modulate this class of glutamatergic receptors. Although dysregulation of AAs modulating NMDARs has been previously reported in SCZ, it remains unclear whether distinct variations of these biomolecules occur during illness progression from at-risk premorbid to clinically manifest stage.
View Article and Find Full Text PDFAge and Hypertension Synergize With Dehydration to Cause Renal Frailty in Rats and Predispose Them to Intrinsic Acute Kidney Injury.
Lab Invest
December 2024
Translational Research on Renal and Cardiovascular Diseases (TRECARD), Department of Physiology and Pharmacology, Universidad de Salamanca, Salamanca, Spain; Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain. Electronic address:
Acute kidney frailty (AKF) is a condition of increased susceptibility to acute kidney injury (AKI), an abrupt impairment of renal excretory function potentially leading to severe complications. Prevention of AKI relies on the recognition of risk factors contributing to AKF. At the population level, dehydration constitutes a predisposing factor for AKI.
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