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Leveraging Microneedles for Raised Scar Management.
Polymers (Basel)
January 2025
Department of Mechanical, Robotics and Energy Engineering, Dongguk University, Jung-gu, Seoul 04620, Republic of Korea.
Disruption of the molecular pathways during physiological wound healing can lead to raised scar formation, characterized by rigid, thick scar tissue with associated symptoms of pain and pruritus. A key mechanical factor in raised scar development is excessive tension at the wound site. Recently, microneedles (MNs) have emerged as promising tools for scar management as they engage with scar tissue and provide them with mechanical off-loading from both internal and external sources.
View Article and Find Full Text PDFEmerging Insights in Keloid Pathogenesis and Therapeutics.
Cutis
November 2024
Noelle Desir is from Weill Cornell Medical College, New York, New York. Iain Noel Encarnacion is from Eastern Virginia Medical School, Norfolk. Dr. Taylor is from the Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Selective inhibition of HSF1 expression in the heat shock pathway of keloid fibroblasts reduces excessive fibrosis in keloid.
Arch Dermatol Res
January 2025
Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan, China.
The stress response following burns may be a crucial factor in keloid formation, yet the underlying pathological mechanisms remain to be elucidated. This study initially investigated how heat shock factor 1 (HSF1) and heat shock proteins (HSPs) within the heat shock pathway influence keloid fibrosis, providing insights into the role of the heat shock response in keloid development. This study aims to further elucidate the role of the heat shock pathway in keloid fibrosis and investigate the specific function of HSF1 within this pathway.
View Article and Find Full Text PDFMicrobial analyses of infectious keloids on the anterior chest-a case-control study.
Arch Dermatol Res
January 2025
Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Some studies have confirmed that pathogens can cause infection through bacterial cultures on the surface of infectious keloids. However, further exploration of the comparison between infectious and non-infectious keloids and the bacterial flora of infectious foci is lacking. To investigate the differential flora of purulent secretions on the surface of infectious keloids compared to non-infectious keloids and to determine the microbial composition within the infectious foci.
View Article and Find Full Text PDFEffects of exosomes from human dental pulp stem cells on the biological behavior of human fibroblasts.
Sci Rep
January 2025
Department of Oral and Maxillofacial Surgery, Guiyang Hospital of Stomatology, Guiyang, 550000, China.
The aim of this study was to investigate the effect of dental pulp stem cell-derived exosomes (DPSCs-Exos) on the biological behaviour of fibroblasts, particularly on keloid fibroblasts (KFs) and normal skin fibroblasts (NFs), with a view to providing new insights into cellular regenerative medicine. We obtained DPSCs-Exos by ultracentrifugation and co-cultured it with KFs and NFs. We detected its effect on cell proliferation using the CCK-8 assay; cell migration ability by cell scratch and Transwell assays; extracellular matrix synthesis using the hydroxyproline content assay; the expression levels of genes associated with fibrosis by PCR assay; and the expression levels of proteins related to fibrosis in the cells using the Western Blot method.
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