AI Article Synopsis
- For centuries, herbs like aloe vera and flax seed oil have been used for their health benefits, particularly regarding the central nervous system.
- A study examined the effects of valproic acid (an anticonvulsant) and herbal treatments on cognitive function and anxiety-related behaviors in rats, with groups receiving control, valproic acid, aloe vera, or flax seed oil.
- Results indicated that aloe vera and flax seed oil improved cognitive function and reduced anxiety while valproic acid impaired memory and increased acetylcholinesterase activity, contrasting the positive effects of the herbs.
Article Abstract
For centuries, herbs and herbal oils are used for pharmacological purpose. Aloe vera is well-known as silent healer and flax seed oil is known to contain rich amount of omega-3 fatty acids, both are having effects on central nervous system. Valproic acid is anticonvulsant drug with some side effects and has shown effects on behaviors. This study was designed to monitor the effects of valproic acid, aloe vera and flax seed oil on cognitive and anxiolytic behaviors in rats. Animals were categorized into four groups: Control, valproic acid, aloe vera and flax seed oil which were respectively treated with water, valproic acid (300mg/kg), aloe vera (0.4ml/kg) and flax seed oil (1.8ml/kg). The treatment was continued 2 weeks for drug and 3 weeks for aloe vera and flax seed oil. Anxiolytic effect as well as increased GABA levels were observed following drug and oil treatments. Improvement in cognitive function with decrease in acetylcholine esterase activity in aloe vera and flax seed oil while impairment in learning memory with increase acetylcholine esterase activity was observed in rats treated with valproic acid. Results showed substantial decrease in acetylcholinesterase level in aloe vera and flax seed oil supporting the cognitive impact of oils in contrary to drug.
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