Amide functional groups are an essential linkage that are found in peptides, proteins, and pharmaceuticals and new methods are constantly being sought for their formation. Here, a new method for their preparation is presented where germanium amides PhGeNR convert acid fluorides directly to amides. These germanium amides serve to abstract the fluorine atom of the acid fluoride and transfer their amide group -NR to the carbonyl carbon, and so function as amidation reagents.
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| http://dx.doi.org/10.1039/d1dt00754h | DOI Listing |
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