A new treatment for static forehead rhytides: Autologous fibroblast and keratin injection.

Objective: To assess the effectiveness of injection of autologous keratin gel and fibroblast for static forehead rhytides rectification as new soft tissue filler.

Materials And Methods: Totally, 48 volunteers suffering static forehead rhytides received the injection of autologous keratin and fibroblast, and 6 volunteers received botulinum toxin type A (BTX-A) and hyaluronic acid (HA) treatment as parallel control. The follow-up study was carried out at 1, 3, 6, 12, and 24 months after treatment, and photographs and satisfactions questionnaire were collected and assessed. All volunteers were independently assessed by blinded evaluators using global aesthetic improvement scores (GAIS). One-way Anova was used for statistical analysis, and the significant level was α=0.05).

Results: The static forehead rhytides were improved observably after the treatment. It still showed good result even at month 24 after the injection. There are no severe adverse effects observed in the whole procedure.

Conclusion: Autologous fibroblast and keratin combined injection might be an ideal therapy in mini-invasive plastic injection area, which is safe and effective for static forehead rhytides correction, and has a long-term efficacy.