Household fine particulate matter (PM ) pollution greatly impacts residents' health. To explore the current national situation of household PM pollution in China, a study was conducted based on literature published from 1998 to 2018. After extracting data from the literature in conformity with the requirements, the nationwide household-weighted mean concentration of household PM (HPL) was calculated. Subgroup analyses of spatial, geographic, and temporal differences were also done. The estimated overall HPL in China was 132.2 ± 117.7 μg/m . HPL in the rural area (164.3 ± 104.5 μg/m ) was higher than that in the urban area (123.9 ± 122.3 μg/m ). For HPLs of indoor sampling sites, the kitchen was the highest, followed by the bedroom and living room. There were significant differences of geographic distributions. The HPLs in the South were higher than the North in four seasons. The inhaled dose of household PM among school-age children differed from provinces with the highest dose up to 5.9 μg/(kg·d). Countermeasures should be carried out to reduce indoor pollution and safeguard health urgently.
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http://dx.doi.org/10.1111/ina.12843 | DOI Listing |
Transplantation
January 2025
Department of Surgery, CORELAB, University of California, Los Angeles, Los Angeles, CA.
Background: Despite efforts to ensure equitable access to liver transplantation (LT), significant disparities remain. Although prior literature has considered the effects of patient sex, race, and income, the contemporary impact of community socioeconomic disadvantage on outcomes after waitlisting for LT remains to be elucidated. We sought to evaluate the association of community-level socioeconomic deprivation with survival after waitlisting for LT.
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January 2025
Department of Medicine-Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA.
Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtained from tumor tissue of each individual patient to stimulate T cell responses against up to 20 neoantigens. This ongoing phase 1 study evaluated autogene cevumeran as monotherapy (n = 30) and in combination with atezolizumab (n = 183) in pretreated patients with advanced solid tumors.
View Article and Find Full Text PDFSci Rep
December 2024
Prospecting and Environment Laboratory (Promediam), Universidad Politecnica de Madrid, Alenza 4, 28003, Madrid, Spain.
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December 2024
University of East London, London, UK.
Environments are dynamic and complex. Some children experience more predictable early life environments than others. Here, we consider how moment-by-moment complexity and predictability in our early environments influence development.
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