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Electrochemical Measurements Reveal Reactive Oxygen Species in Stress Granules*. | LitMetric

Electrochemical Measurements Reveal Reactive Oxygen Species in Stress Granules*.

Angew Chem Int Ed Engl

Department of Chemistry and Molecular Biology, University of Gothenburg, Kemivägen 10, 41296, Gothenburg, Sweden.

Published: July 2021

AI Article Synopsis

Article Abstract

Stress granules (SGs) are membrane-less organelles that assemble in the cytoplasm to organize cellular contents and promote rapid adaptation during stress. To understand how SGs contribute to physiological functions, we used electrochemical measurements to detect electroactive species in SGs. With amperometry, we discovered that reactive oxygen species (ROS) are encapsulated inside arsenite-induced SGs, and H O is the main species. The release kinetics of H O from single SGs and the number of H O molecules were quantified. The discovery that SGs contain ROS implicates them as communicators of the cellular stresses rather than a simple endpoint. This may explain how SGs regulate cellular metabolism and stress responses. This may also help better understand their cytoprotective functions in pathological conditions associated with SGs such as neurodegenerative diseases (NDs), cancers and viral infections.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456511PMC
http://dx.doi.org/10.1002/anie.202104308DOI Listing

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