The fruit extract of Momordica charantia Linn. was studied in Charles Foster rats of both sexes in respect of its dose-response hypoglycemia and at maximal effective dose, its influence on the development of diabetic cataract. Alloxan (120 mg/kg s.c./rat, single dose) diabetic rats with greater than 150 mg% of blood sugar were classified into four groups (n = 10) wherein two were control and the rest were test groups). In the test group, the oral dose response hypoglycemic herbal effect was found to be maximum at 4 g/kg/Day/rat when administered for 20 days. This dose was continued in the 2nd test group for a period of 2 months. Blood sugar in all the rats was estimated by microdetermination method using a dextrometer before and after therapy. The control group of rats received 2 ml of 0.9% NaCl and they developed cataract in 90 to 100 days. The herbal treated diabetics showed cataract in 140 to 180 days. Cataract formation was found to be dependant on blood sugar levels since the control group with blood sugar 307 +/- 81 (mg%) was blind 2 months earlier than herbal treated group which showed blood sugar 149 +/- 66.37 (mg%).
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http://dx.doi.org/10.1016/s0031-6989(88)80041-9 | DOI Listing |
Medicine (Baltimore)
November 2024
Department of Cardiology, Rabta Teaching Hospital, University of Medicine Tunis, Tunis, Tunisia.
Little is known about the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on atherosclerosis. We aimed to determine if a 90-day intake of Dapagliflozin could improve atherosclerosis biomarkers (namely endothelial function assessed by flow-mediated dilatation [FMD] and carotid intima-media thickness [CIMT]) in diabetic and non-diabetic acute coronary syndrome (ACS) patients when initiated in the early in-hospital phase. ATH-SGLT2i was a prospective, single-center, observational trial that included 113 SGLT2i naive patients who were admitted for ACS and who were prescribed Dapagliflozin at a fixed dose of 10 mg during their hospital stay for either type 2 diabetes or for heart failure.
View Article and Find Full Text PDFTrop Anim Health Prod
January 2025
Animal Science Department, Federal University of Paraná, Palotina, PR, 85950-000, Brazil.
This study aimed to evaluate the effect of autolyzed yeast (obtained from culture of Saccharomyces cerevisiae in sugarcane derivatives) supplementation on diet digestibility, feeding behavior, levels of blood metabolites associated with protein and energy metabolism, and performance of Dorper × Santa Ines lambs finished in feedlot. Twenty-four non-castrated male lambs with an average age of 4 months and a body weight (BW) of 19.49 ± 3.
View Article and Find Full Text PDFMed J Malaysia
January 2025
Occupational and Safety Unit, Selangor State Health Department, Ministry of Health, Selangor, Malaysia.
Introduction: Cardiovascular diseases (CVDs) remain to be the leading cause of premature mortality worldwide, and healthcare workers (HCWs) are potentially at risk for developing CVDs. Office-based Globorisk is a ten-year risk prediction tool for CVDs risk scores. This present study aims to determine the prevalence of CVDs risk and risk factors associated with moderate-high CVDs risk among primary HCWs in government health clinics in Selangor.
View Article and Find Full Text PDFGinekol Pol
January 2025
Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Objectives: This study investigates the relationship between serum homocysteine, blood lipids, and perinatal outcomes in patients with diet-controlled gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT).
Material And Methods: A prospective cohort of 150 diet-controlled GDM patients and 150 pregnant women with NGT, all delivering at our hospital, were selected based on predefined criteria. Data on demographics, physical parameters, and perinatal outcomes were compiled.
Tunis Med
January 2025
Department of Endocrinology and Internal Medicine, Fattouma Bourguiba Hospital, Monastir. Tunisia.
Unlabelled: Introduction-Aim: Type 2 diabetes (T2D) is a major public health problem. To succeed its management and prevent its complications, good therapeutic adherence must be ensured. The objectives of our work were to estimate the prevalence of poor therapeutic adherence in our patients and to identify its associated factors.
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