Prothymosin α promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation.

Mitochondrion

Department of Oncology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China. Electronic address:

Published: July 2021

Colorectal cancer (CRC) affects millions of people worldwide. Chemoresistance seriously impairs the therapeutic effects. Lipid droplets (LDs) abnormally accumulate in CRC supported chemoresistance. Exploring the mechanism of LD-induced chemoresistance is extremely important for improving prognosis of CRC patients. The expression of PTMA was increased in both CRC tissues and cells, which was positively correlated with LD production. PTMA facilitated chemoresistance to gemcitabine by inducing LD production in CRC cells. PTMA enhanced LD biogenesis and chemoresistance to gemcitabine by promoting SREBP-1-mediated lipogenesis and STAT3 activation in CRC.

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http://dx.doi.org/10.1016/j.mito.2021.04.001DOI Listing

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