The catalytic asymmetric synthesis of hexahydro-furofuran-3-ol, a key fragment of HIV protease inhibitors, is reported. A signature event is represented by the sequential metal catalysis that combines the Pd-catalyzed asymmetric hydroalkoxylation of ene-alkoxyallene and ring-closing metathesis (RCM). Notably, this unprecedented and highly chemoselective approach allows for a unified access to pyranofuranol and furopyranol derivatives.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c00981 | DOI Listing |
Publication Analysis
Top Keywords
catalytic asymmetric
8
asymmetric synthesis
8
synthesis hexahydro-furofuran-3-ol
8
hexahydro-furofuran-3-ol pyran
4
pyran derivatives
4
derivatives catalytic
4
hexahydro-furofuran-3-ol key
4
key fragment
4
fragment hiv
4
hiv protease
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!