AI Article Synopsis
- Resonant X-ray emission spectroscopy (RXES) is an advanced technique developed over the past decade to analyze the chemical states of metal complexes and observe chemical reactions.
- The study focused on using RXES to track how osmium(VI) nitrido complexes convert to osmium(III) ammine states when reduced by glutathione, a significant biological reducing agent.
- The RXES results align with previous theoretical predictions and suggest the formation of osmium(IV) intermediates, supporting a pathway that may enhance the anticancer effects of these metal complexes when reduced inside cells.
Article Abstract
Resonant X-ray emission spectroscopy (RXES) has developed in the past decade as a powerful tool to probe the chemical state of a metal center and study chemical reactions. We have used it to monitor spectral changes associated with the reduction of osmium(VI) nitrido complexes to the osmium(III) ammine state by the biologically relevant reducing agent, glutathione. RXES difference maps are consistent with the proposed DFT mechanism and the formation of two stable osmium(IV) intermediates, thereby supporting the overall pathway for the reduction of these high-valent anticancer metal complexes for which reduction by thiols within cells may be essential to the antiproliferative activity.
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| http://dx.doi.org/10.1021/acs.inorgchem.1c00467 | DOI Listing |
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