AI Article Synopsis
- The article discusses two projects aimed at creating drugs for tropical diseases like Malaria, African sleeping sickness, and Chagas disease, primarily based in a University environment.
- It highlights the collaboration with pharmaceutical companies to transition from initial drug discovery to clinical trial readiness.
- The two specific cases examined are the development of inhibitors for protein farnesyltransferase and a group of compounds called benzthiazoles, which are under investigation for their effectiveness.
Article Abstract
In this Viewpoint, we provide a brief description of two efforts to develop drugs to treat diseases caused by tropical parasites (Malaria, human African trypanosomiasis and Chagas disease). These efforts are largely based in a University setting but draw heavily on Pharma for a complete progression from drug hit discovery to advancement toward clinical trials. The first case is the development of protein farnesyltransferase inhibitors, and the second case is a series of benzthiazoles, the target of which is being investigated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323184 | PMC |
| http://dx.doi.org/10.1021/acsinfecdis.1c00091 | DOI Listing |
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