A novel -pimarane-type diterpenoid, sigesbeckia J (), along with two known diterpenoids, siegesbeckia acid () and -18-acetoxy-16,17-dihydroxykauran-19-oic acid (), were isolated from the aerial parts of Makino. Their chemical structures were elucidated based on extensive spectroscopic interpretation. The absolute configuration of -pimarane-type diterpenoid () was determined by comparing experimental and calculated ECD spectra. Compared with the positive control minocycline (IC 32.84 μM), compound exhibited moderate cell growth anti-inflammatory activities by testing their inhibition of LPS-induced NO production in BV2 microglial cells, with IC value of 58.74 μM.
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