Intrathecal antibody kinetics in neuroborreliosis: A report on three cases and a literature review.

Infect Dis Now

Service de médecine interne, institut mutualiste Montsouris, 42, boulevard Jourdan, 75014 Paris, France. Electronic address:

Published: October 2021

Borreliosis is a common affliction in northern countries and its neurological manifestations often mislead trained clinicians. We present three cases of Lyme neuroborreliosis, with intrathecal synthesis of specific antibodies, lymphocytic meningitis and magnetic-resonance imaging (MRI) findings. Our description aims at illustrating the natural history of the infection, highlighting persistent intrathecal synthesis of anti-Borrelia antibodies months after treatment completion, and its clinical significance. We then review the literature on MRI findings in neuroborreliosis and the kinetics of intrathecal synthesis of specific anti-Borrelia antibodies.

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http://dx.doi.org/10.1016/j.idnow.2021.02.006DOI Listing

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