A unique Rh(III)-catalyzed C-H activation/[3 + 2] annulation of -phenoxyacetamides has been developed for the construction of dihydrobenzofurans via carbooxygenation of 1,3-dienes. This transformation features a redox-neutral process with specific chemoselectivity, good substrate/functional group compatibility, and profound synthetic potentials. A preliminary exploration to realize their asymmetric synthesis have been also successfully demonstrated, which further strengthens the practicality of this approach.
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| http://dx.doi.org/10.1021/acs.orglett.1c00945 | DOI Listing |
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