We report radiolabeling of thiol-containing substrates via Pd-catalyzed S-arylation with 2-[F]fluoro-5-iodopyridine, which is readily accessible using the "minimalist" radiofluorination method. The practicality of the procedure was confirmed by preparation of a novel PSMA-specific PET-tracer as well as labeling of glutathione, Aβ oligomer-binding RD2 peptide, bovine serum albumin and PSMA I&S.
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| http://dx.doi.org/10.1039/d1cc00745a | DOI Listing |
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