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Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice.
Biomed Pharmacother
December 2023
Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address:
Haloperidol, one of the representative typical antipsychotics, is on the market for schizophrenia but shows severe adverse effects such as extrapyramidal symptoms (EPS) or cognitive impairments. Oleanolic acid (OA) is known to be effective for tardive dyskinesia which is induced by long-term treatment with L-DOPA. This study aimed to investigate whether OA could ameliorate EPS or cognitive impairment induced by haloperidol.
View Article and Find Full Text PDFReply to Response to Vacuous standards - Subversion of the OSAC standards-development process.
Forensic Sci Int Synerg
May 2021
Departments of Mathematics and Statistics, Northwestern University, Evanston, IL, USA.
This Letter to the Editor is a reply to Mohammed et al. (2021) https://doi.org/10.
View Article and Find Full Text PDFResponse to vacuous standards subversion of the OSAC standards development process.
Forensic Sci Int Synerg
March 2021
American Academy of Forensic Sciences, Academy Standards Board (AAFS-ASB), United States.
Optically Tunable Tin Oxide-Coated Hollow Gold-Silver Nanorattles for Use in Solar-Driven Applications.
ACS Omega
September 2020
Department of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, Texas 77204, United States.
Core@shell metal nanoparticles have emerged as promising photocatalysts because of their strong and tunable plasmonic properties; however, marked improvements in photocatalytic efficiency are needed if these materials are to be widely used in practical applications. Accordingly, the design of new and functional light-responsive nanostructures remains a central focus of nanomaterial research. To this end, we report the synthesis of nanorattles comprising hollow gold-silver nanoshells encapsulated within vacuous tin oxide shells of adjustable thicknesses (∼10 and ∼30 nm for the two examples prepared in this initial report).
View Article and Find Full Text PDFEffects of CATECHIN on reserpine-induced vacuous chewing movements: behavioral and biochemical analysis.
Naunyn Schmiedebergs Arch Pharmacol
December 2020
ªPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
This study evaluated the effect of (+)-catechin, a polyphenolic compound, on orofacial dyskinesia (OD) induced by reserpine in mice. The potential modulation of monoaminoxidase (MAO) activity, tyrosine hydroxylase (TH) and glutamic acid decarboxylase (GAD) immunoreactivity by catechin were used as biochemical endpoints. The interaction of catechin with MAO-A and MAO-B was determined in vitro and in silico.
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