AI Article Synopsis
- The study analyzed high-resolution ultrasonography with color Doppler (HRUS with CD) for diagnosing inflammatory activity in leprosy patients during type 1 and 2 reactions, comparing it to nerve conduction studies (NCS).
- A total of 257 nerves from 35 patients were assessed, revealing that HRUS with CD diagnosed inflammatory activity in 74% of cases, slightly higher than the 68% diagnosed by NCS; when both methods were used together, the detection rate rose to 91.4%.
- The findings suggest that HRUS with CD is particularly effective for detecting leprosy reactions, especially in cases with minimal changes observable via NCS or when no motor response is present.
Article Abstract
Objective: To analyze the role of high-resolution ultrasonography with color Doppler (HRUS with CD) to diagnose inflammatory activity (IA) in nerves of leprosy patients under type 1 (RT1) and 2 (RT2) reactions compared to Nerve Conduction Studies (NCS).
Methods: Leprosy patients with signs or symptoms suggestive of neuritis (RT1 and RT2) without corticosteroids use were selected. They were evaluated by NCS and subsequently by HRUS with CD. Subacute segmental demyelination and the presence of blood flow, respectively, were considered signs of IA. The two methods were compared for their ability to diagnose patients with leprosy reactions.
Results: A total of 257 nerves from 35 patients were evaluated. NCS and HRUS with CD diagnosed IA in 68% and 74% of patients, respectively. When both methods were used concomitantly, the diagnosis rate was 91.4%. HRUS with CD was particular helpful when there was minimal neurophysiological compromise in NCS or when motor potentials were not detected.
Conclusion: HRUS with CD was able to detect leprosy reactions, especially when combined with NCS. It was especially useful in two opposite situations: nerves with only minor changes and those without motor response in NCS.
Significance: Our data shows the usefulness of HRUS and CD, similar to NCS, as a tool to diagnose leprosy reactions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047122 | PMC |
| http://dx.doi.org/10.1016/j.cnp.2021.02.003 | DOI Listing |
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