The tumor microenvironment (TME) has an essential role in the development of cervical squamous cell carcinoma (CSCC); however, the dynamic role of the stromal and immune cells is still unclear in TME. We downloaded data from The Cancer Genome Atlas (TCGA) database and applied ESTIMATE and CIBERSORT algorithms to measure the quantity of stromal and immune cells and the composition of tumor-infiltrating immune cell (TIC) in 253 CSCC cases. The protein-protein interaction (PPI) network and Cox regression analysis presented the differentially expressed genes (DEGs). Then, C-C chemokine receptor type 7 () was screened out as a prognostic marker by the univariate Cox and intersection analysis of PPI. Further analysis showed a positive correlation between the expression of and the survival of CSCC patients. The result of the Gene Set Enrichment Analysis (GSEA) of genes in the high expression group displayed a predominant enrichment in immune-related pathways. An enrichment in metabolic activities was observed in the low expression group. CIBERSORT analysis showed a positive correlation between Plasma cells, CD8 T cells, and regulatory T cells and the expression, suggesting that might play a crucial role in maintaining the immunological dominance status for TME. Therefore, the expression level of might help predict the survival of CSCC cases and be an index that the status of TME transitioned from immunological dominance to metabolic activation, which presented a new insight into the treatment of CSCC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047428 | PMC |
| http://dx.doi.org/10.3389/fmolb.2021.583028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single-center retrospective study.
Laryngoscope Investig Otolaryngol
February 2025
Department of Otolaryngology, Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao China.
Introduction: Systemic inflammatory and nutritional markers are associated with the prognosis of various cancers. However, their association with sinonasal squamous cell carcinoma (SNSCC) prognosis remains unclear. This study aimed to identify systemic inflammatory and nutritional markers associated with the postoperative prognosis of patients with SNSCC and to clarify the clinical value of these markers.
View Article and Find Full Text PDFKIF18A and CDK1 as combined therapeutic targets in cervical and endometrial carcinomas: based on bioinformatics analysis and experiments.
Transl Cancer Res
December 2024
Department of Gynecology, the First Hospital of Weinan City, Weinan, China.
Background: Chromosomal instability (CIN) has been identified as a factor that increases the susceptibility of tumor cells to kinesin family member 18A (KIF18A) inhibitors. Limited research exists on genes that are associated with sensitization to KIF18A inhibitors (KIF18Ais). Our study aimed to identify a gene linked to heightened sensitivity to KIF18Ais in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and uterine corpus endometrial carcinoma (UCEC).
View Article and Find Full Text PDFPseudovascular squamous cell carcinoma of the buccal mucosa-a rare case report and review of literature.
Ecancermedicalscience
November 2024
Department of Oncopathology, Dr. B. Borooah Cancer Institute, Guwahati 781016, Assam, India.
Squamous cell carcinoma is the most common malignancy of the head and neck. Pseudovascular squamous cell carcinoma (PSCC) is a rare variant that occurs commonly in the skin of the head and neck. However, oral cavity involvement is extremely rare, with only a few cases reported to date.
View Article and Find Full Text PDFImpact of Local Extent of Tumor on the Survival Outcomes for Surgically Treated Tongue Cancers.
Head Neck
January 2025
Head and Neck Oncology Department, Tata Memorial Hospital and HBNI, Mumbai, India.
Background: The current classification of tongue cancers does not discriminate stages based on factors of local spread.
Aim: Integrating factors of local spread that impact disease-specific survival (DSS) in a modified classification to improve prognostication compared with the current staging.
Method: This was a retrospective analysis of 399 previously untreated oral tongue squamous carcinomas operated between 2016 and 2018.
Assessment of Surgical Margin of Tongue Squamous Cell Carcinoma via Raman Mapping.
Oral Dis
January 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Objectives: This study introduces a novel classification approach that combines convolutional neural network (CNN) and Raman mapping to differentiate between tongue squamous cell carcinoma (TSCC) and non-tumorous tissue, as well as to identify different histological grades of TSCC.
Materials And Methods: In this study, 240 Raman mappings data from 30 tissue samples were collected from 15 patients who had undergone surgical resection for TSCC. A total of 18,000 sub-mappings extracted from Raman mappings were then used to train and test a CNN model, which extracted feature representations that were subsequently processed through a fully connected network to perform classification tasks based on the Raman mapping data.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!