A 56-year-old male patient with no significant clinical history manifested lumbar pain, macroscopic hematuria and dysuria. Radiology images found a renal mass in the upper right pole at the pyelocaliceal level. A partial nephrectomy was performed to resect the tumor, and histology revealed the diagnosis of a renal epidermoid cyst, which is an infrequent lesion with a benign biological behavior. Its etiology is still controversial, but its clinical course is satisfactory after complete resection of the lesion.
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http://dx.doi.org/10.1016/j.eucr.2021.101649 | DOI Listing |
Am J Physiol Cell Physiol
March 2025
Department of Dermatology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
The bone hormone fibroblast growth factor 23 (FGF23) regulates renal phosphate reabsorption and the enzymatic production of active vitamin D (1,25(OH)D). Therefore, FGF23 production in bone cells is closely regulated by 1,25(OH)D acting via the vitamin D receptor (VDR). Skin cells can produce hydroxyvitamin D metabolites from its precursor D made through UVB-light exposure.
View Article and Find Full Text PDFDiagn Pathol
February 2025
Department of Diagnostic Pathology, Tokyo Women's Medical University, Adachi Medical Center, Tokyo, Japan.
Background: Low-grade oncocytic tumor (LOT) of the kidney is an emerging entity among renal oncocytic tumors. While the histological features of LOT of the kidney are similar to those of renal oncocytoma, LOT immunohistochemically expresses keratin 7 (KRT7) but not KIT while renal oncocytoma expresses KIT. Molecular analyses of LOTs of the kidney using next generation sequencing revealed those tumors harbor mutations of mTOR-related genes.
View Article and Find Full Text PDFInt J Surg Pathol
February 2025
Department of Surgery, Znojmo Hospital, Znojmo, Czech Republic.
Clear cell renal cell carcinoma (CCRCC) displays a variety of architectural patterns, which are often intermingled. However, a predominant or purely multicystic growth with diffuse intracystic hemorrhage leading to hemangioma-like histomorphology, is extremely rare in CCRCC. In this article, we describe a CCRCC exhibiting a pure hemangioma-like architecture and aggressive behavior.
View Article and Find Full Text PDFInt J Surg Pathol
December 2024
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India.
Smooth muscle and adenoma-like renal tumor (SMART) is a biphasic tumor composed of cytologically bland stromal and epithelial components. It has many histopathological mimickers. A 57-year-old man presented with a left renal mass.
View Article and Find Full Text PDFPathology
February 2025
Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a renal neoplasm associated with FH loss, aggressive behaviour, and poor survival. We present a histopathological and immunohistochemical overview of FH-deficient RCC to infer significant features for its differential diagnosis. In this study, FH-deficient RCC tissue samples from patients who underwent surgical resection or biopsy at a single institution between July 1995 and August 2022 were reviewed by conventional haematoxylin and eosin staining, immunohistochemistry, and whole genome analyses.
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