Brown adipose tissue of cervical, supraclavicular, and paravertebral regions can show increased FDG uptake. But human white adipose tissue (WAT) shows negligible FDG uptake on 18F-FDG PET/CT scan. We present a case of carcinoma cervix treated with concurrent chemoradiation. 18F-FDG PET/CT shows altered biodistribution of FDG with intense FDG uptake throughout the WAT. Later on, patient confirmed taking herbal medication for herpes zoster infection, which could contain corticosteroids, resulting in enhanced WAT uptake of 18F-FDG.
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http://dx.doi.org/10.1097/RLU.0000000000003652 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, 12622, Egypt.
The main goal of the current study is to estimate the in vivo anti-inflammatory/antioxidant ability of four selected pharmaceutical compounds: bisoprolol (Biso), piracetam (Pirc), clopidogrel (Clop), and cinnarizine (Cinna). Indomethacin (Indo) was used as a reference drug to perform a realistic comparison between the four compounds and the Indo in vivo through tracking PI3K/AKT signaling and computational chemistry via density functional theory (DFT) modeling to analyze the electrostatic potential across the molecule and provide insight into the regions for receptor binding of the studied compounds. To achieve the safe dose of these compounds, cytotoxicity was performed against isolated adipose tissue-derived mesenchymal stem cells (ADMSCs) using MTT assay.
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January 2025
College of Animal Science and Technology, Anhui Agricultural University, Hefei, China.
Pregnant ewes mobilize body fat to increase energy supply for fetal growth and development upon undernutrition, which disrupts the metabolic homeostasis of the body. However, the comprehensive metabolic changes in subcutaneous adipose tissue upon undernutrition are poorly understood. In this study, an undernutrition sheep model was established to investigate the effects of undernutrition on metabolic changes, immune response, and inflammation in subcutaneous fat through transcriptome, RT-qPCR, and metabolome analysis.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Background: Obesity in midlife is a risk factor for developing Alzheimer disease later in life. However, the metabolic and inflammatory effects of body fat varies based on its anatomical localization. In this study, we aimed to investigate the association of MRI-derived abdominal visceral and subcutaneous adipose tissue (VAT and SAT), liver proton-density fat fraction (PDFF), thigh fat-to-muscle ratio (FMR), and insulin resistance with whole-brain amyloid burden in cognitively normal midlife individuals.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.
Background: Women's reproductive experiences may enact reorganization of physiological systems with lifelong health consequences. We test the hypothesis that women's history of breastfeeding will be positively associated with neurocognitive benefits in post-menopausal women. This hypothesis is justified by breastfeeding's well-established benefits for mothers' glucose homeostasis, beta-cell function, adipose tissue mobilization, and lipid metabolism, which would plausibly be beneficial for later-life brain health.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Herbert and Jackeline Krieger Klein Alzheimer's Research Center, Rutgers Biomedical and Health Sciences, Newark, NJ, USA.
Background: While body mass index (BMI) is widely used to gauge overall adiposity, its accuracy in older age has yielded inconsistent findings. Moreover, BMI does not account for variations in regional fat distribution, which may differ between sexes. This study aims to investigate whether regional adiposity plays a distinct role in impacting cognition and the volumes of AD-related brain regions in older adults with T2D enrolled in the Israel Diabetes and Cognitive Decline (IDCD) study.
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