AI Article Synopsis
- * This case report describes two patients with advanced gastric cancer who developed adrenal insufficiency after receiving chemotherapy and the ICI tislelizumab, with symptoms appearing after 6 and 13 treatment cycles.
- * Both patients were effectively treated with hydrocortisone for adrenal insufficiency and levothyroxine for hypothyroidism, showing promising responses to the therapy, including one patient achieving a near-complete response lasting over 11 months.
Article Abstract
Immune checkpoint inhibitor (ICI)-associated adrenal insufficiency is rare but may become a serious adverse event in patients treated with ICIs. The present case report documents two cases of adrenal insufficiency developed during chemotherapy plus tislelizumab (, Baize'an; BeiGene Ltd.) therapy in patients with advanced gastric cancer. Adrenal insufficiency developed after 6 and 13 cycles of treatment and was well controlled with hydrocortisone. The patients also developed hypothyroidism, which was managed with levothyroxine. Two patients showed a partial response, and one patient out of two achieved a near-complete response, sustaining over 11 months. Increased awareness of ICI-related adrenal insufficiency is crucial for early detection and prompt management of patients treated with ICIs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895967 | PMC |
| http://dx.doi.org/10.12701/yujm.2021.00934 | DOI Listing |
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