AI Article Synopsis
- The study explores the relationship between psychotic symptoms and prodromal Parkinson's disease (PD) in participants aged 65 and older who do not have dementia or PD.
- Researchers used specific scales to identify new psychotic features that appeared during a three-year follow-up, determining participants' likelihood of having prodromal PD based on established criteria.
- Findings showed that individuals who exhibited psychotic symptoms were 1.3 times more likely to have signs of prodromal PD, with factors like depression, constipation, and mild movement issues being significant contributors to this association.
Article Abstract
Introduction: Some case series have suggested that psychotic features could occur even before the onset of motor symptoms of Parkinson's Disease (PD). Our aim was to investigate a possible association between psychotic symptoms and prodromal Parkinson's disease in a population-based cohort, the Hellenic Longitudinal Investigation of Aging and Diet study.
Methods: This cross-sectional study included participants aged ≥65 years without dementia or PD. We defined psychotic symptoms as the presence of at least one new hallucinatory or delusional feature, assessed with the Neuropsychiatric Inventory scale and the Columbia University Scale for Psychopathology in Alzheimer's Disease, exhibited only at follow-up and not present at baseline visit. We calculated the probability of prodromal PD (pPD) for every participant, according to the 2019 International Parkinson and Movement Disorders Society research criteria for prodromal PD.
Results: Participants who developed psychotic manifestations over a three-year follow up (20 of 914) had 1.3 times higher probability of pPD score (β [95%CI]: 1.3 [0.9-1.5], p=0.006) compared to non-psychotic subjects. This association was driven mostly by depressive symptoms, constipation and subthreshold parkinsonism (p<0.05).
Conclusion: Our data indicate that emerging psychotic features evolve in parallel with the probability of pPD. This is the first study that provides evidence for the presence of psychotic experiences in pPD. The association detected needs to be confirmed in longitudinal studies.
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| http://dx.doi.org/10.1016/j.parkreldis.2021.04.001 | DOI Listing |
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