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Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito and Its Capacity to Mobilize Pantothenate and Biotin.
Biomolecules
January 2025
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA.
Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes. We previously demonstrated that Pan is not only essential for mosquito survival, but also for the development of malaria parasites within the mosquito, suggesting that targeting Pan and CoA biosynthesis may be a novel approach for malaria control. However, little is known about how Pan is acquired and mobilized within the mosquito.
View Article and Find Full Text PDFGene drive-based population suppression in the malaria vector Anopheles stephensi.
Nat Commun
January 2025
Center for Bioinformatics, Center for Life Sciences, School of Life Sciences, Peking University, Beijing, China.
Gene drives are alleles that can bias the inheritance of specific traits in target populations for the purpose of modification or suppression. Here, we construct a homing suppression drive in the major urban malaria vector Anopheles stephensi targeting the female-specific exon of doublesex, incorporating two gRNAs and a nanos-Cas9 to reduce functional resistance and improve female heterozygote fitness. Our results show that the drive was recessive sterile in both females and males, with various intersex phenotypes in drive homozygotes.
View Article and Find Full Text PDFA systematic review of interventions targeting .
Wellcome Open Res
December 2024
Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
Background: , a malaria mosquito originally from South Asia and the Middle East, has been expanding across both Asia and Africa in recent decades. The invasion of this species into sub-Saharan Africa is of particular concern given its potential to increase malaria burden, especially in urban environments where thrives. Whilst surveillance of this vector in Africa has recently increased markedly there is a need to review the existing methods of control so that we can stop, rather than simply monitor, its spread in Africa.
View Article and Find Full Text PDFThermal variation influences the transcriptome of the major malaria vector Anopheles stephensi.
Commun Biol
January 2025
Department of Infectious Diseases, University of Georgia, Athens, GA, USA.
The distribution and abundance of ectothermic mosquitoes are strongly affected by temperature, but mechanisms remain unexplored. We describe the effect of temperature on the transcriptome of Anopheles stephensi, an invasive vector of human malaria. Adult females were maintained across a range of mean temperatures (20 °C, 24 °C and 28 °C), with daily fluctuations of +5 °C and -4 °C at each mean temperature.
View Article and Find Full Text PDFSeasonal plasticity in daily timing of flight activity in is driven by temperature modulation of dawn entrainment.
Philos Trans R Soc Lond B Biol Sci
January 2025
Chronobiology Section, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
The Asian malaria vector is invading Africa, requiring it to adapt to novel climates and ecosystems. In part, this may be facilitated by 's poorly understood seasonal behavioural plasticity in flight timing, leading to earlier biting activity in cold Asian winters and later biting times in the warm summer. Changes in behavioural timing could be directly imposed by seasonal variation in ambient light and temperature levels or result from altered entrainment of intrinsically expressed circadian rhythms by these factors.
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