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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051184 | PMC |
| http://dx.doi.org/10.1183/13993003.04397-2020 | DOI Listing |
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The relationship between mixed venous blood oxygen saturation and pulmonary arterial and venous pressures in patients with heart failure.
Physiol Rep
November 2024
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Article Synopsis
- - Recent research has found that intrapulmonary bronchopulmonary anastomoses (IBAs) create common right-to-left shunts in the lungs and may significantly influence heart failure's pathophysiology.
- - The study involved 237 heart failure patients and assessed the relationship between mixed venous oxygen saturation (SvO₂) and various pulmonary pressures, finding that lower SvO₂ levels correlate with increased pulmonary artery systolic pressure (sPAP) and pulmonary artery wedge pressure (PAWP).
- - Results indicate that decreased SvO₂ is linked to increased sPAP and PAWP, likely due to IBAs, while left ventricular end-diastolic pressure (LVEDP) did not show a
Surgical Management Of Congenital Thoracic Disorders: A 15-Year Center Experience.
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July 2024
Thoracic Surgery Department - Hospital de Santa Marta, Centro Hospitalar Universitário Lisboa Central, Portugal.
Introduction: Congenital thoracic disorders represent a spectrum of fetal lung bud development abnormalities, which may affect breathing capacity and quality of life. We aim to evaluate the impact of surgery in the treatment of 4 major congenital conditions.
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Bilateral pulmonary sequestrations: Distinct types sharing a common celiac artery origin, presented with pneumonia and associated findings in a pediatric case.
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Radiology Department, Denizli State Hospital, Denizli, Turkey.
A 14-year-old boy presented with shortness of breath, cough, and mild chest pain, with a history of intermittent milder symptoms. Physical examination and initial tests showed mild iron deficiency anemia, elevated C-reactive protein, and normal vital signs. Chest radiograph revealed abnormalities in the left lower zone, leading to contrast-enhanced chest CT.
View Article and Find Full Text PDFCauses of Hypoxemia in COVID-19 Acute Respiratory Distress Syndrome: A Combined Multiple Inert Gas Elimination Technique and Dual-energy Computed Tomography Study.
Anesthesiology
February 2024
Department of Anesthesiology, University Medical Center of Göttingen, Göttingen, Germany.
Background: Despite the fervent scientific effort, a state-of-the art assessment of the different causes of hypoxemia (shunt, ventilation-perfusion mismatch, and diffusion limitation) in COVID-19 acute respiratory distress syndrome (ARDS) is currently lacking. In this study, the authors hypothesized a multifactorial genesis of hypoxemia and aimed to measure the relative contribution of each of the different mechanism and their relationship with the distribution of tissue and blood within the lung.
Methods: In this cross-sectional study, the authors prospectively enrolled 10 patients with COVID-19 ARDS who had been intubated for less than 7 days.
Aggrecan accumulates at sites of increased pulmonary arterial pressure in idiopathic pulmonary arterial hypertension.
Pulm Circ
January 2023
Department of Experimental Medical Science, Faculty of Medicine Lund University Lund Sweden.
Expansion of extracellular matrix occurs in all stages of pulmonary angiopathy associated with pulmonary arterial hypertension (PAH). In systemic arteries, dysregulation and accumulation of the large chondroitin-sulfate proteoglycan aggrecan is associated with swelling and disruption of vessel wall homeostasis. Whether aggrecan is present in pulmonary arteries, and its potential roles in PAH, has not been thoroughly investigated.
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