Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD nonpeptidergic neurons that restrain MC activation via glutamate secretion.
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| http://dx.doi.org/10.1016/j.cell.2021.03.040 | DOI Listing |
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